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Percentages of treatment intolerability outcomes by AE trajectory groups. The 4 clusters of bar graphs from left to right indicate the incidence rate of AEs per cycle, drug modification in any cycle, early treatment discontinuation due to any reason, and discontinuation due to an AE. **P < .01, and ***P < .001 for all pairwise comparisons with the Low AE Traj group. AE indicates adverse event; Discont, discontinuation.
