Table 4.
Clinical Characteristics of the CRKP and CSKP Groups of Hospital-Acquired KP BSI
| Items | CSKP (n=87) | CRKP (n=84) | Z /χ2 | P value |
|---|---|---|---|---|
| Male | 48(55.2%) | 66(78.6%) | 10.530 | 0.001 |
| Age | 59(49.0-68.0) | 51.5(37.0-64.0) | -2.334 | 0.020 |
| Total length of hospital stay | 27(13.0-37.0) | 32.5(20.0-62.0) | -3.125 | 0.002 |
| Death in 28 days | 12(13.8%) | 45(53.6%) | 30.430 | <0.001 |
| Admission history within 90 days | 38(43.7%) | 24(28.6%) | 4.220 | 0.040 |
| Any antibiotics exposure | 38(43.7%) | 75(89.3%) | 39.661 | <0.001 |
| Carbapenems exposure | 16(18.4%) | 49(58.3%) | 28.937 | <0.001 |
| BLBLIs exposure | 21(24.1%) | 54(64.3%) | 27.976 | <0.001 |
| Hypertension | 19(21.8%) | 33(39.3%) | 6.147 | 0.013 |
| Diabetes | 18(20.7%) | 15(17.9%) | 0.220 | 0.639 |
| Chronic kidney disease | 9(10.3%) | 23(27.4%) | 8.154 | 0.004 |
| Coronary heart disease | 9(10.3%) | 7(8.3%) | 0.204 | 0.652 |
| Cerebral infarction | 7(8.0%) | 17(20.2%) | 5.265 | 0.022 |
| Intracerebral hemorrhage | 3(3.4%) | 15(17.9%) | 9.421 | 0.002 |
| Liver cirrhosis | 2(2.3%) | 9(10.7%) | 5.028 | 0.025 |
| Solid tumor | 16(18.4%) | 3(3.6%) | 9.503 | 0.002 |
| Hematological malignancies | 27(31.0%) | 13(15.5%) | 5.773 | 0.016 |
| Solid organ transplantation | 3(3.4%) | 25(29.8%) | 21.610 | <0.001 |
| Immunosuppressive state | 34(39.1%) | 37(44.0%) | 0.434 | 0.510 |
| CCI score>2 | 18(20.7%) | 16(19.0%) | 0.072 | 0.788 |
| Admission to ICU | 16(18.4%) | 49(58.3%) | 28.937 | <0.001 |
| Complicated pulmonary infection | 18(20.7%) | 44(52.4%) | 18.572 | <0.001 |
| Mechanical ventilation > 48 hours | 11(12.6%) | 36(42.9%) | 19.574 | <0.001 |
| Sputum aspiration | 15(17.2%) | 46(54.8%) | 26.219 | <0.001 |
| Nasogastric tube | 22(25.3%) | 53(63.1%) | 24.810 | <0.001 |
| CVC | 18(20.7%) | 55(65.5%) | 35.038 | <0.001 |
| PICC | 22(25.3%) | 18(21.4%) | 0.355 | 0.551 |
| Peripheral arterial catheter | 12(13.8%) | 34(40.5%) | 15.474 | <0.001 |
| Blood purification | 5(5.7%) | 25(29.8%) | 17.038 | <0.001 |
| Bronchoscopy | 1(1.1%) | 9(10.7%) | 5.470 | 0.019 |
| Thoracentesis | 2(2.3%) | 15(17.9%) | 11.554 | 0.001 |
| Abdominal puncture | 2(2.3%) | 10(11.9%) | 6.044 | 0.014 |
| Bone marrow puncture | 20(23.0%) | 10(11.9%) | 3.629 | 0.057 |
| Lumbar puncture | 6(6.9%) | 6(7.1%) | 0.004 | 0.950 |
| In hospital operation | 33(37.9%) | 38(45.2%) | 0.940 | 0.332 |
| Emergency surgery | 5(5.7%) | 15(17.9%) | 6.068 | 0.014 |
| Altered mental status | 13(14.9%) | 42(50.0%) | 24.073 | <0.001 |
| Septic shock | 9(10.3%) | 31(36.9%) | 16.824 | <0.001 |
| Pitt bacteremia score≥4 | 12(13.8%) | 37(44.0%) | 19.135 | <0.001 |
Note: aP values less than 0.05 are bolded.
Abbreviations: ICU, intensive care unit; CCI, Charlson comorbidity index; CVC, central venous catheters; PICC, peripherally inserted central venous catheters; BLBLIs, β-lactam/β-lactamase inhibitor combinations.