Table 6.
Univariate Analysis of Risk Factors Associated with 28-Day Mortality in Patients with Hospital-Acquired KP BSI
| Items | Survival (n=114) | Death (n=57) | Z /χ2 | P value |
|---|---|---|---|---|
| Male | 70(61.4%) | 44(77.2%) | 4.263 | 0.039 |
| Age | 55.5(43.8-66.0) | 56(37.5-68.5) | -0.067 | 0.946 |
| Total length of hospital stay | 30(17.0-52.5) | 22(16.5-38.5) | -1.927 | 0.054 |
| CRKP BSI | 39(34.2%) | 45(78.9%) | 30.430 | <0.001 |
| Early appropriate therapya | 76(66.7%) | 26(45.6%) | 6.997 | 0.008 |
| Any antibiotics exposure | 65(57.0%) | 48(84.2%) | 12.537 | <0.001 |
| Carbapenems exposure | 33(28.9%) | 32(56.1%) | 11.925 | 0.001 |
| BLBLIs exposure | 40(35.1%) | 35(61.4%) | 10.688 | 0.001 |
| Diabetes | 21(18.4%) | 12(21.1%) | 0.169 | 0.681 |
| Solid tumor | 15(13.2%) | 4(7.0%) | 1.451 | 0.228 |
| Hematological malignancies | 28(24.6%) | 12(21.1%) | 0.261 | 0.609 |
| Chronic kidney disease | 23(20.2%) | 9(15.8%) | 0.481 | 0.488 |
| Solid organ transplantation | 17(14.9%) | 11(19.3%) | 0.534 | 0.465 |
| Immunosuppressive state | 48(42.1%) | 23(40.4%) | 0.048 | 0.826 |
| CCI score>2 | 24(21.1%) | 10(17.5%) | 0.294 | 0.588 |
| Admission to ICU | 28(24.6%) | 43(75.4%) | 40.510 | <0.001 |
| Complicated pulmonary infection | 29(25.4%) | 43(75.4%) | 38.972 | <0.001 |
| Septic shock | 12(10.5%) | 37(64.9%) | 54.979 | <0.001 |
| Altered mental status | 21(18.4%) | 34(59.6%) | 29.603 | <0.001 |
| Pitt bacteremia score≥4 | 14(12.3%) | 35(61.4%) | 44.852 | <0.001 |
| Mechanical ventilation> 96 hours | 19(16.7%) | 40(70.2%) | 48.146 | <0.001 |
| CVC | 34(29.8%) | 42(73.7%) | 29.605 | <0.001 |
| PICC | 31(27.2%) | 15(26.3%) | 0.015 | 0.903 |
| Peripheral arterial catheter | 16(14.0%) | 34(59.6%) | 38.214 | <0.001 |
| Blood purification | 14(12.3%) | 20(35.1%) | 12.408 | <0.001 |
| Bronchoscope | 6(5.3%) | 10(17.5%) | 6.757 | 0.009 |
| Sputum aspiration | 28(24.6%) | 43(75.4%) | 40.510 | <0.001 |
| Thoracentesis | 9(7.9%) | 13(22.8%) | 7.538 | 0.006 |
| Bone marrow puncture | 23(20.2%) | 12(21.1%) | 0.018 | 0.893 |
| Leukopenia | 33(28.9%) | 13(22.8%) | 0.729 | 0.393 |
| HGB <90g/L | 55(48.2%) | 36(63.2%) | 3.394 | 0.065 |
| RDW-CV >15 | 33(28.9%) | 30(52.6%) | 9.161 | 0.002 |
| PLT counts <100×109/L | 47(41.2%) | 36(63.2%) | 7.316 | 0.007 |
| Albumin <30g/L | 28(24.6%) | 20(35.1%) | 2.085 | 0.149 |
| TBIL >2 ULN | 8(7.0%) | 13(22.8%) | 8.794 | 0.003 |
| Elevated serum creatinine | 27(23.7%) | 27(47.4%) | 9.865 | 0.002 |
| PT >16S | 20(17.5%) | 27(47.4%) | 16.959 | <0.001 |
Notes: aP values less than 0.05 are bolded; bThe antibiotics selected for the first time were consistent with the drug sensitivity results.
Abbreviations: ICU, intensive care unit; CRKP, carbapenem-resistant Klebsiella pneumoniae; BSI, bloodstream infection; CCI, Charlson comorbidity index; CVC, central venous catheters; PICC, peripherally inserted central venous catheters; HGB, hemoglobin; RDW-CV, coefficient of variation of red blood cell distribution width; PLT, platelet; TBIL, total bilirubin; PT, prothrombin time; ULN, the upper limit of normal; BLBLIs, β-lactam-β-lactamase inhibitor combinations.