Table 3.
Clinical results.
| Study | Follow up (month) | MST (months) | Type for RT | Patients (n) | 1-year OS (%) | 2-year OS (%) | Responser (n) | CR (%) | PR (%) | SD (%) | PD (%) | ORR (%) | LCR (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hou et al. | 10 | CRT | 181 | 181 | 29.3 | 31.5 | 33.7 | 5.5 | 60.8 | 94.5 | |||
| Tan et al. | 14.3 | 8 | CRT | 26 | 23 | 4 | 26 | 8 | 31 | 61 | 39 | ||
| Toya et al. | 9.6 | CRT | 38 | 39.4 | 17.5 | 38 | 15.8 | 28.9 | 44.7 | 10.5 | 44.7 | 89.4 | |
| Igaki et al. | 5.6 | CRT | 18 | 33.3 | 9 | 12 | 16.7 | 16.7 | 58.3 | 8.3 | 33.4 | 91.7 | |
| Tanaka et al. | 9.4 | CRT | 67 | 39 | 9 | 67 | 7.5 | 37.3 | 23.9 | 31.3 | 44.8 | 68.7 | |
| Okazaki et al. | 5.3 | 6.4 | CRT | 56 | 50 | 0 | 22 | 44 | 34 | 22 | 66 | ||
| Iwamoto et al. | 13.3 | CRT | 80 | 56 | 26.7 | ||||||||
| Yu et al. | 8 | 11.6 | CRT | 281 | 48.1 | 26.9 | 260 | 3.85 | 54.23 | 27.69 | 14.23 | 58.08 | 85.77 |
| Rim et al. | 13.9 | CRT | 45 | 51.5 | 45 | 6.7 | 55.6 | 31 | 6.7 | 62.3 | 93.3 | ||
| Bae et al. | 8 | CRT | 47 | 15 | 15 | 47 | 0 | 40 | 51 | 9 | 40 | 91 | |
| Huang et al. | 3.8 | CRT | 326 | 16.7 | 5.5 | ||||||||
| Yeh et al. | 10 | 7 | CRT | 106 | 34.7 | 11 | 106 | 9.5 | 52 | 33 | 5.5 | 61.5 | 94.5 |
| Pao et al. | 4.4 | 6.6 | CRT | 42 | 30 | 19 | 27 | 14.8 | 59.3 | 25.9 | 0 | 74.1 | 100 |
| Onishi et al. | 12.4 | CRT+HAIC | 33 | 54.5 | 22 | 31 | 3.2 | 45.2 | 45.2 | 6.5 | 48.4 | 93.6 | |
| Kodama et al. | 9.9 | CRT+HAIC | 36 | 47 | 20.3 | 36 | 8.3 | 41.7 | 50 | 0 | 50 | 100 | |
| Han et al. | 13.5 | CRT+HAIC | 152 | 60 | 29.5 | 152 | 1.3 | 46.7 | 34.2 | 17.8 | 48 | 82.2 | |
| Tang et al. | 10.7 | 12.3 | CRT+TACE | 185 | 51.6 | 28.4 | |||||||
| Lu et al. | 13.02 | CRT+TACE | 30 | 62.4 | 20.81 | 30 | 16.7 | 53.3 | 20 | 10 | 70 | 90 | |
| Yamada et al. | 7 | CRT+TACE | 19 | 40.6 | 10.2 | 19 | 0 | 57.9 | 42.1 | 0 | 57.9 | 100 | |
| Shirai et al. | 9.4 | 10.3 | CRT+TACE | 19 | 47.4 | 23.7 | 19 | 0 | 36.8 | 52.6 | 10.5 | 36.8 | 89.4 |
| Yoon et al. | 10.6 | 10.6 | CRT+TACE | 412 | 42.5 | 22.8 | 409 | 6.6 | 33 | 46 | 14.4 | 39.6 | 85.6 |
| Yoon et al. | 12.8 | CRT+TACE | 45 | 53.3 | 26.8 | 45 | 0 | 28.9 | 51.1 | 20 | 28.9 | 80 | |
| Yu et al. | 11.4 | CRT+TACE +hyperthermia |
69 | 85 | 62.9 | 69 | 34 | 36.2 | 15.3 | 14.5 | 70.2 | 85.5 | |
| Sugahara et al. | 21 | 22 | PRT | 35 | 68 | 48 | 35 | 22.8 | 60 | 8.6 | 8.6 | 82.8 | 91.4 |
| Hashimoto et al. | 8.4 | PRT | 34 | 55 | 34 | 15 | 47 | 35 | 3 | 62 | 97 | ||
| Komatsu et al. | PRT | 31 | 47 | 24 | |||||||||
| Sekino et al. | 21 | PRT | 21 | 62 | 33 | ||||||||
| Lee et al. | 13.2 | 13.2 | PRT | 27 | 55.6 | 33.3 | 27 | 0 | 55.6 | 37 | 7.4 | 55.6 | 92.6 |
| Kim et al. | 15.2 | 34.4 | PRT | 41 | 73.2 | 51.1 | 41 | 34.2 | 48.8 | 14.3 | 2.4 | 83 | 97.3 |
| Xi et al. | 10 | 13 | SBRT | 41 | 50.3 | 41 | 36.6 | 39 | 17.1 | 7.3 | 75.6 | 92.7 | |
| Shui et al. | 9.5 | 10 | SBRT | 70 | 40 | 62 | 9.7 | 69.4 | 6.4 | 14.5 | 79.1 | 85.5 | |
| Lou et al. | 10 | SBRT | 75 | 38.7 | 13.3 | 75 | 22.7 | 73.3 | 4 | 0 | 96 | 100 | |
| Dutta et al. | 6 | 11.4 (mean) | SBRT | 72 | 38 | 10 | 54 | 0 | 36 | 42 | 22 | 36 | 78 |
| Kumar et al. | 8 | 15 | SBRT | 29 | 60 | 29 | 7 | 80 | 13 | 87 | |||
| Wang et al. | 7.4 | 9.6 (mean) | SBRT | 20 | 58 | 22 | 36.4 | 31.8 | 27.3 | 4.4 | 68.2 | 95.5 | |
| Choi et al. | 8.4 | 20.8 | SBRT | 24 | 67.5 | 48.2 | 24 | 8.3 | 45.8 | 29.2 | 16.7 | 54.1 | 83.3 |
| Hou et al. | 11.8 | 10.46 | CRT | 64 | 35.8 | 16 | 64 | 1.6 | 51.6 | 12.5 | 34.3 | 53.2 | 65.7 |
| 15.47 | CRT | 54 | 59.3 | 32 | 54 | 5.6 | 64.8 | 9.3 | 20.3 | 70.4 | 79.7 | ||
| Zhao et al. | 13 | 19 | CRT+TACE+Sorafenib | 28 | 72.4 | 48 | 28 | 10.7 | 35.7 | 28.6 | 25 | 46.4 | 75 |
| 14.1 | 15.2 | CRT+TACE | 35 | 77.5 | 16 | 35 | 0 | 45.7 | 31.4 | 22.9 | 45.7 | 77.1 | |
| Li et al. | 31 | 10 | CRT | 154 | 48.1 | 25.1 | |||||||
| 10 | SBRT | 133 | 46.5 | 29.3 | |||||||||
| Nomura et al. | 6.7 | CRT+HAIC | 18 | 21 | 6 | 32 | 9.4 | 50 | 21.9 | 18.7 | 59.4 | 81.3 | |
| 49.2 | CRT+HAIC+Sorafenib | 14 | 75 | 50 | |||||||||
| Lin et al. | 6 | SBRT | 22 | 14 | 7 | 71 | 21 | 0 | 78 | 100 | |||
| 6.7 | CRT | 21 | |||||||||||
| Yang et al. | 10.9 | SBRT | 54 | 34.9 | 15.3 | 45 | 11.1 | 51.1 | 33.33 | 4.4 | 62.2 | 95.53 | |
| 4.7 | CRT | 86 | 15.7 | 8 | 59 | 8.5 | 25.4 | 45.8 | 20.3 | 33.9 | 79.7 | ||
| Que et al. | 13.22 (mean) | 12.5 | SBRT+Sorafenib | 18 | 55.6 | 17.7 | 18 | 33.33 | 44.44 | 11.11 | 11.11 | 77.77 | 88.88 |
| 15.33 (mean) | 7 | SBRT | 36 | 33.3 | 11.1 | 36 | 25 | 50 | 2.78 | 22.22 | 75 | 77.78 | |
| Khorprasert et al. | 8.2 | 7.9 | CRT | 140 | 39.1 | 16.5 | 119 | 18.5 | 55.5 | 8.4 | 17.6 | 74 | 82.4 |
| 11.9 | SBRT | 20 | 45 | 22 | |||||||||
Red font means overall survival in 1st year; overall survival in 2nd year.