Table 4.
Comparison of pooled outcomes among groups.
| Groups | Cohorts (n) | Patients (n) | p, Heterogeneity | I2 | Pooled rates (95% CI) | p | p | |
|---|---|---|---|---|---|---|---|---|
| (among three groups) | (between two groups) | p, Egger’s test, | ||||||
| 1-year OS | ||||||||
| Overall | 48 | 3450 | 0 | 87.1 | 47.3 (42.3, 52.4) | 0.04 | ||
| CRT | 30 | 2669 | 0 | 89.1 | 45.3 (38.6, 52.1) | Q=11.006, p=0.004 | PRT vs CRT | 0.25 |
| Q=8.060, p=0.005 | ||||||||
| SBRT | 12 | 592 | 0.098 | 36.6 | 44.9 (39.5, 50.3) | SBRT vs CRT | 0.114 | |
| Q=0.009, p=0.926 | ||||||||
| PRT | 6 | 189 | 0.254 | 22.9 | 60.9 (52.6, 68.9) | PRT vs SBRT Q=9.922, p=0.002 | 0.39 | |
| CRT + TACE | 7 | 745 | 0.001 | 73 | 53.2 (44.2, 62.2) | Q=7.856, p= 0.020 | CRT+TACE vs CRT+HAIC | 0.165 |
| Q=0.351, p=0.554 | ||||||||
| CRT + HAIC | 4 | 239 | 0.0012 | 72.8 | 48.0 (33.4, 62.7) | CRT vs CRT+HAIC | 0.128 | |
| Q=1.970, p=0.160 | ||||||||
| CRTal | 16 | 1574 | 0 | 90.1 | 36.1 (28.2, 44.3) | CRT vs CRT+TACE | 0.676 | |
| Q=7.612, p=0.006 | ||||||||
| 2-year OS | ||||||||
| Overall | 42 | 3211 | 0 | 84.7 | 21.9 (18.0, 26.1) | 0.357 | ||
| CRT | 29 | 2624 | 0 | 81.6 | 20.4 (15.9, 25.2) | Q=11.412, p=0.003 | PRT vs CRT | 0.725 |
| Q=10.353, p=0.001 | ||||||||
| SBRT | 8 | 432 | 0.001 | 72.3 | 19.2 (11.9, 27.5) | SBRT vs CRT | 0.991 | |
| Q=0.055, p=0.814 | ||||||||
| PRT | 5 | 155 | 0.128 | 44.1 | 38.5 (28.2, 49.3) | PRT vs SBRT | 0.224 | |
| Q=8.318, p=0.004 | ||||||||
| CRT + TACE | 7 | 745 | 0.466 | 0 | 23.2 (20.1, 26.4) | Q=6.021, p=0.049 | CRT+TACE vs CRT+HAIC | 0.401 |
| Q=0.106, p=0.744 | ||||||||
| CRT + HAIC | 4 | 239 | 0.106 | 50.9 | 21.5 (13.1, 31.2) | CRT vs CRT+HAIC | 0.044 | |
| Q=1.483, p=0.223 | ||||||||
| CRTal | 15 | 1529 | 0 | 85.2 | 15.5 (10.7, 21.0) | CRT vs CRT+TACE | 0.977 | |
| Q=6.020, p=0.014 | ||||||||
| ORR | ||||||||
| Overall | 40 | 2617 | 0 | 87 | 58.1 (52.2, 63.8) | 0.151 | ||
| CRT | 26 | 1941 | 0 | 78.1 | 50.4 (45.1, 55.7) | Q=14.277, p=0.001 | PRT vs CRT | 0.863 |
| Q=7.455, p=0.006 | ||||||||
| SBRT | 10 | 439 | 0 | 88 | 72.7 (58.8, 84.7) | SBRT vs CRT | 0.609 | |
| Q=8.424,p=0.004 | ||||||||
| PRT | 4 | 137 | 0.024 | 68.3 | 72.1 (57.6, 84.7) | PRT vs SBRT | 0.171 | |
| Q=0.003, p=0.956 | ||||||||
| CRT + TACE | 6 | 557 | 0.007 | 68.4 | 45.1 (34.4, 56.0) | Q=0.725, p=0.696 | CRT+TACE vs CRT+HAIC | 0.403 |
| Q=0.247, p=0.619 | ||||||||
| CRT + HAIC | 3 | 219 | – | – | 48.4 (41.7, 55.1) | CRT vs CRT+HAIC | – | |
| Q=0.218, p=0.641 | ||||||||
| CRTal | 14 | 1036 | 0 | 79.1 | 50.7 (43.4, 58.0) | CRT vs CRT+TACE | 0.142 | |
| Q=0.707, p=0.400 | ||||||||
| LCR | ||||||||
| Overall | 38 | 2562 | 0 | 77 | 88.6 (85.5, 91.4) | 0.654 | ||
| CRT | 25 | 1915 | 0 | 77.7 | 86.8 (83.0, 90.3) | Q=7.257, p=0.027 | PRT vs CRT | 0.872 |
| Q=7.213, p=0.007 | ||||||||
| SBRT | 9 | 410 | 0 | 78.4 | 90.4 (82.4, 96.3) | SBRT vs CRT | 0.623 | |
| Q=0.645, p=0.422 | ||||||||
| PRT | 4 | 137 | 0.638 | 0 | 95.1 (90.4, 98.5) | PRT vs SBRT | 0.444 | |
| Q=1.410, p=0.235 | ||||||||
| CRT + TACE | 6 | 557 | 0.007 | 68.9 | 87.0 (80.7, 92.3) | Q=0.962, p=0.618 | CRT+TACE vs CRT+HAIC | 0.403 |
| Q=0.827, p=0.363 | ||||||||
| CRT + HAIC | 3 | 219 | – | – | 93.5 (77.9, 1.0) | CRT vs CRT+HAIC | – | |
| Q=0.949, p=0.330 | ||||||||
| CRTal | 13 | 1010 | 0 | 84.6 | 86.1 (79.6, 91.6) | CRT vs CRT+TACE | 0.599 | |
| Q=0.019, p=0.891 |
CRTal, CRT alone group.
Red font means 2-groups comparison in 1-year OS, 2-year OS, ORR, LCR. Subgroups for CRT, SBRT, and PRT; CRT+TACE, CRT+HAIC, and CRTal.