Table 5.
Comparison of toxic effect events for groups.
| Cohorts | Events | Total | Cohorts | Events | Total | Events rate (95%CI) | I 2 | p | p | |
|---|---|---|---|---|---|---|---|---|---|---|
| for <grade 3 | for ≥grade 3 | (among three groups) | (among two groups) | |||||||
| Hepatotoxicity | ||||||||||
| CRT | 11 | 997 | 1007 | 13 | 178 | 1303 | 12.1 (6.8, 18.6) | 87.7 | PRT vs CRT | |
| Q=13.059, p=0.000 | ||||||||||
| SBRT | 5 | 152 | 139 | 6 | 40 | 209 | 14.7 (4.8, 28.1) | 80.2 | Q=16.0.39, p=0 | SBRT vs CRT |
| Q=0.198, p=0.656 | ||||||||||
| PRT | 2 | 7 | 68 | 4 | 2 | 127 | 6 (0, 3.8) | 11 | PRT vs SBRT | |
| Q=8.605, p=0.003 | ||||||||||
| Hematological | ||||||||||
| CRT | 11 | 650 | 774 | 12 | 171 | 658 | 17.6 (7.8, 30.3) | 92.7 | PRT vs CRT | |
| Q=8.58, p=0.003 | ||||||||||
| SBRT | 3 | 87 | 95 | 4 | 18 | 165 | 10.8 (11.2, 28.6) | 88.3 | Q=8.97, p=0.011 | SBRT vs CRT |
| Q=0.50, p=0.482 | ||||||||||
| PRT | 3 | 31 | 103 | 4 | 3 | 128 | 2.2 (0.1, 6.9) | 45.5 | PRT vs SBRT | |
| Q=1.996, p=0.158 | ||||||||||
| Gastrointestinal | ||||||||||
| CRT | 20 | 879 | 1951 | 17 | 62 | 1529 | 2.8 (0.6, 6.1) | 85.8 | PRT vs CRT | |
| Q=3.654, p=0.056 | ||||||||||
| SBRT | 7 | 141 | 268 | 6 | 1 | 193 | 0.1 (0, 1.8) | – | Q=4.374, p= 0.112 | SBRT vs CRT |
| Q=2.687, p=0.101 | ||||||||||
| PRT | 1 | 3 | 35 | 4 | 0 | 128 | 0 | – | PRT vs SBRT | |
| Q=0.201, p=0.654 | ||||||||||
| Dermatological | ||||||||||
| CRT | 5 | 62 | 268 | 4 | 0 | 226 | 0 | – | PRT vs SBRT | |
| Q=0.080, p=0.778 | ||||||||||
| SBRT | 8 | 2 | 54 | 2 | 2 | 54 | 0.15 (0, 7.8) | – | Q=3.396, p=0.183 | PRT vs CRT |
| Q=1.728, p=0.189 | ||||||||||
| PRT | 2 | 44 | 56 | 4 | 3 | 121 | 0.1 (0, 5.8) | – | SBRT vs CRT | |
| Q=2.375, p=0.123 |
Red font means 2-groups comparison in Hepatotoxicity, Hematological, Gastrointestinal, Dermatological. Subgroups for CRT, SBRT, and PRT.