Table 2:
Predictors of High Vaginal TFV Levels
| Vaginal TFV level ≥1000 ng/mL | Vaginal TFV level <1000 ng/mL | P-value | |
|---|---|---|---|
|
| |||
| DBS TFV-DP ≥700 fmol/punch | 13 | 14 | 1.00 |
| DBS TFV-DP <700 fmol/punch | 3 | 4 | |
|
| |||
| DBS TFV-DP ≥1250 fmol/punch | 4 | 9 | 0.17 |
| DBS TFV-DP <1250 fmol/punch | 12 | 9 | |
|
| |||
| Plasma estrogen ≥100 pg/mL | 13 | 13 | 0.70 |
| Plasma estrogen <100 pg/mL | 3 | 5 | |
|
| |||
| Gardnerella positive | 9 | 2 | 0.02 |
| Gardnerella negative | 5 | 10 | |
|
| |||
| Candida positive | 1 | 1 | 1.00 |
| Candida negative | 13 | 11 | |
|
| |||
| HSV/CMV positive | 2 | 2 | 1.00 |
| HSV/CMV negative | 15 | 15 | |
|
| |||
| HPV16/18 positive | 3 | 3 | 1.00 |
| HPV16/18 negative | 11 | 10 | |
|
| |||
| L. crispatus dominant | 2 | 5 | 0.41 |
| Other vaginal type | 13 | 13 | |
|
| |||
| Lactobacillus dominant | 5 | 13 | 0.30 |
| Non-Lactobacillus dominant | 7 | 5 | |
|
| |||
| Elevated cytokines | 12 | 15 | 0.68 |
| No elevated cytokines | 3 | 4 | |
|
| |||