Table 4.
Metabolite relaxation times of NAA, creatine and choline methyl singlet groups at 2.0 ppm, 3.0 ppm, and 3.2 ppm, respectively, reported in normal neonates at different fields. All data are given in milliseconds (mean ± SD).
| Region | B0 (T) | Ref | T1 (ms) |
T2 (ms) |
Age (GA w) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NAA | Cr | Cho | mI | Lac | NAA | Cr | Cho | mI | Lac | ||||
| Occ GM | 1.5 | [153] | 930 ± 476 | 1620 ± 529 | 1320 ± 370 | 1520 ± 529 | - | 524 ± 207 | 228 ± 29 | 431 ± 98 | 301 ± 66 | - | T1: 41 ± 1 T2: 42 ± 3 |
| Occ WM | 2.4 | [152] | 1220 ± 280a | 1600 ± 700a | 1130 ± 220a | - | 1230 ± 420a | 463.5 ± 129.6 | 198.4 ± 42.3 | 498.4 ± 239.7 | - | 241.9 ± 119.9 | T1: N/A; T2: 35.2 (mean) |
| Thal | 2.4 | [151] | 1310 ± 310 | 1660 ± 640 | 1180 ± 220 | - | 1280 ± 440 | 638.9 ± 68.1 | 199.2(192.4–225.3) | 383.6 ± 84.2 | - | 221.8(196.3–287.7) | 39 ± 1.8 |
| Thal | 2.4 | [150] | - | - | - | - | - | 316.3 ± 78.4 | 209.1 ± 35.8 | 327.8 ± 87.5 | - | 231.5 ± 53.5 | 32–42 (range) |
| Thal | 2.4 | [152] | 1220 ± 280 | 1600 ± 700 | 1130 ± 220 | - | 1230 ± 420 | 331 ± 90.6 | 204 ± 35.2 | 343.7 ± 99.9 | - | 244.4 ± 107.1 | T1: N/A; T2: 35.2 (mean) |
| Thal | 3 | [76] | 1410 ± 220 | 1600 ± 200 | 1150 ± 180 | - | - | 480 ± 100 | 205 ± 17 | 430 ± 70 | - | - | 40 ± 2 |
Abbreviations: Occ Occipital, Thal thalamus, GM gray matter, WM white matter, NAA N-acetylaspartate, Cr creatine, Cho choline, mI myo-inositol, Lac lactate, w week, GA gestational age.
a
T1 estimates were only reported for the Thalamus but found to be similar in Occ