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. 2022 Jan 28;4(2):fcac010. doi: 10.1093/braincomms/fcac010

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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SWDs were dose- and time-dependently induced by ArchT. Summary graphs (left) showing the feeding regimen (DOX or normal chow) and the corresponding level of ArchT-GFP expression; charts (middle) presenting the average SWDs/h; and IHC images (right) of the TRN showing GFP (green, representing ArchT) in PV neurons (magenta) and the merged image of the two, scale bar, 200 μm. (A) Mice under a normal chow their entire lives (n = 4 mice). (B) Mice with neonatal induction of ArchT (27 ± 3.8 times/h, P60, n = 4 mice). (C) Mice under DOX chow their entire lives (n = 3 mice). (D) Mice with adult induction of ArchT (9.1 ± 0.9 times/h, n = 3 mice). Data are shown as mean ± SEM. *P < 0.05 based on paired t-tests comparing two time points.