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. Author manuscript; available in PMC: 2023 Jan 20.
Published in final edited form as: Mol Cell. 2022 Jan 20;82(2):348–388. doi: 10.1016/j.molcel.2021.12.026

Figure 1. Site-specific DNA perturbations induced by CRISPR-based genome editing technologies and DNA repair processes that resolve them.

Figure 1.

Schematic of the five major CRISPR-based genome editing technologies and six site-specific DNA lesions/structures generated by them. Enzymatic activities of genome editors generating the depicted DNA lesions/structures, DNA repair processes involved in their resolution, and outcomes of the repair events are also illustrated. BER (base excision repair), HDR (homology-directed repair), MMR (mismatch repair), SSBR (single-strand break repair) and TLS (translesion synthesis).