Table 2.
Baseline characteristics stratified by H2FPEF score category.
| Low score⁎ | Intermediate score⁎ | High score⁎ | p-Value | |
|---|---|---|---|---|
| n | 40 | 72 | 44 | |
| Age | 60.00 [50.75, 74.00] | 67.00 [56.75, 78.00] | 74.00 [66.00, 81.00] | 0.014 |
| Male (%) | 23 (57.5) | 34 (47.2) | 17 (38.6) | 0.224 |
| BMI | 26.95 [22.25, 29.40] | 33.20 [25.55, 39.24] | 31.20 [27.95, 36.05] | <0.001 |
| Race (%) | 0.325 | |||
| White | 9 (22.5) | 22 (30.6) | 17 (39.5) | |
| Other | 12 (30.0) | 14 (19.4) | 11 (25.6) | |
| Black | 19 (47.5) | 36 (50.0) | 15 (34.9) | |
| Comorbidities | ||||
| Current smoker (%) | 2 (5.1) | 0 (0.0) | 0 (0.0) | 0.052 |
| Atrial fibrillation (%) | 2 (5.0) | 11 (15.3) | 33 (75.0) | <0.001 |
| Coronary artery disease (%) | 19 (47.5) | 39 (54.2) | 28 (63.6) | 0.324 |
| Hypertension (%) | 35 (87.5) | 67 (93.1) | 42 (95.5) | 0.373 |
| Chronic kidney disease (%) | 17 (42.5) | 40 (55.6) | 20 (45.5) | 0.345 |
| COPD (%) | 5 (12.5) | 7 (9.7) | 10 (22.7) | 0.140 |
| Diabetes mellitus (%) | 21 (52.5) | 45 (62.5) | 27 (61.4) | 0.564 |
| Asthma (%) | 7 (17.5) | 10 (13.9) | 12 (27.3) | 0.194 |
| Cancer (%) | 11 (27.5) | 17 (23.6) | 12 (27.3) | 0.865 |
| Ventricular arrhythmia (%) | 2 (5.0) | 5 (6.9) | 10 (22.7) | 0.011 |
| Stroke (%) | 16 (40.0) | 20 (27.8) | 12 (27.3) | 0.340 |
| Acute myocardial infarction (%) | 8 (20.0) | 18 (25.0) | 10 (22.7) | 0.833 |
| DVT or pulmonary embolism (%) | 8 (20.0) | 19 (26.4) | 17 (38.6) | 0.149 |
| Labs | ||||
| Troponin | 0.02 [0.01, 0.06] | 0.05 [0.02, 0.10] | 0.04 [0.02, 0.09] | 0.231 |
| White blood cell count | 6.42 [4.57, 7.68] | 5.58 [4.18, 7.08] | 7.65 [5.39, 10.15] | 0.003 |
| Lymphocyte number | 0.99 [0.70, 1.45] | 0.90 [0.63, 1.35] | 1.09 [0.70, 1.35] | 0.468 |
| Hemoglobin | 11.85 [9.88, 12.50] | 10.85 [9.17, 12.93] | 12.65 [10.57, 13.75] | 0.024 |
| Platelet Count | 156.50 [128.25, 225.25] | 188.00 [142.50, 244.75] | 240.50 [168.75, 300.50] | 0.002 |
| Creatinine | 1.19 [0.83, 1.96] | 1.60 [0.93, 2.86] | 1.36 [0.99, 2.47] | 0.291 |
| CRP | 82.70 [19.50, 138.10] | 81.10 [37.08, 145.25] | 67.00 [31.02, 122.67] | 0.778 |
| Ferritin | 567.00 [251.18, 1381.13] | 832.50 [276.53, 1993.75] | 453.00 [187.43, 872.60] | 0.088 |
| LDH | 265.00 [226.50, 387.50] | 326.50 [234.50, 380.75] | 296.50 [246.25, 404.50] | 0.672 |
| Vital signs | ||||
| Systolic BP | 131.50 [112.75, 151.25] | 131.50 [118.50, 149.00] | 130.00 [112.75, 149.00] | 0.732 |
| Diastolic BP | 73.50 [61.75, 82.25] | 71.00 [61.00, 79.25] | 76.00 [58.75, 94.00] | 0.403 |
| Heart Rate | 90.50 [87.00, 105.00] | 90.50 [77.50, 99.00] | 87.00 [73.75, 98.25] | 0.357 |
| Respiratory Rate | 18.00 [18.00, 20.00] | 20.00 [18.00, 22.00] | 21.00 [18.00, 24.00] | 0.006 |
| Pulse Oximetry | 97.00 [93.00, 98.00] | 97.00 [93.00, 98.25] | 96.00 [92.75, 97.00] | 0.397 |
| Temperature | 98.95 [98.12, 99.80] | 99.25 [98.38, 100.03] | 98.45 [97.65, 99.32] | 0.024 |
ULN = upper limit of normal; BMI = body mass index; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disorder; DVT = deep venous thrombosis; CRP = c-reactive protein; LDH = lactate dehydrogenase; BP = blood pressure.
⁎
Low, intermediate, and high score groups defined as H2FPEF scores from 0 to 2, 3–5, and 6–9, respectively.