Figure 7.
Effect of KDM6 inhibitor (GSKJ4) on IH-evoked sympathetic nerve activation and elevated BP in rats. A: systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure expressed as difference between post- and pre-IH and B: Plasma norepinephrine levels in male rats exposed to IH10d treatment with either vehicle (IH) or GSKJ4 (10 mg/kg/day ip). Data are means ± SE from 6 rats per group. **P ≤ 0.05; ns: not significant (P > 0.05) as determined by one-way ANOVA. BP, blood pressure; IH, intermittent hypoxia; KDM, lysine demethylases; N, normoxia; TBP, TATA-binding protein; veh, vehicle.