Table 4.
Effect of Intervention and Covariates on Markers of Inflammation in Two-Level Mixed Models
| TNF-± | IL-10 | IL-8 | IL-6 | CRP | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||
| Coef. (SE) | β | P | Coef. (SE) | β | P | Coef. (SE) | β | P | Coef. (SE) | β | P | Coef. (SE) | β | P | |
| Intercept | .50 (.04) | 11.78 | .000 | .34 (.10) | 3.60 | .000 | .96 (.07) | 13.56 | .000 | .51 (.10) | 4.89 | .000 | .70 (.17) | 4.17 | .000 |
| Intervention | −.01 (.02) | −.69 | .492 | −.01 (.05) | −.13 | .894 | .02 (.04) | .54 | .592 | −.10 (.05) | −1.93 | .053 | −.10 (.09) | −1.10 | .270 |
| CBSM vs. HP | |||||||||||||||
| Time | |||||||||||||||
| 6 mo. vs. Baseline | −.08 (.02) | −5.04 | .000 | −.16 (.03) | −5.10 | .000 | −.06 (.02) | −2.88 | .004 | −.08 (.04) | −1.85 | .064 | −.01 (.07) | −.20 | .840 |
| 12 mo. vs. Baseline | .01 (.02) | .57 | .568 | −.08 (.04) | −2.01 | .044 | −.03 (.02) | −1.03 | .304 | .09 (.05) | 1.77 | .077 | .11 (.07) | 1.47 | .143 |
| Intervention*Time | |||||||||||||||
| CBSM | |||||||||||||||
| 6 mo. vs. Baseline | −.07 (.02) | −4.37 | .000 | −.12 (.03) | −3.85 | .000 | −.09 (.02) | −4.09 | .000 | −.07 (.05) | −1.55 | .121 | .00 (.07) | .04 | .972 |
| 12 mo. vs. 6 mo. | .07 (.02) | 4.06 | .000 | .06 (.03) | 1.91 | .056 | .06 (.02) | 2.85 | .004 | .13 (.05) | 2.70 | .007 | .05 (.07) | .66 | .511 |
| HP | |||||||||||||||
| 6 mo. vs. Baseline | −.08 (.02) | −5.04 | .000 | −.16 (.03) | −5.10 | .000 | −.06 (.02) | −2.88 | .004 | −.08 (.04) | −1.85 | .064 | −.01 (.07) | −.20 | .840 |
| 12 mo. vs. 6 mo. | .09 (.02) | 5.24 | .000 | .08 (.03) | 2.29 | .022 | .03 (.02) | 1.53 | .126 | .17 (.05) | 3.55 | .000 | .12 (.07) | 1.66 | .096 |
| CBSM vs. HP | |||||||||||||||
| at Baseline | −.01 (.02) | −.69 | .492 | −.01 (.05) | −.13 | .894 | .02 (.04) | .54 | .592 | −.10 (.05) | −1.93 | .053 | −.10 (.09) | −1.10 | .270 |
| at 6 mo. | −.01 (.02) | −.23 | .816 | .03 (.05) | .59 | .557 | −.01 (.04) | −1.20 | .839 | −.09 (.06) | −1.54 | .123 | −.08 (.09) | −.86 | .391 |
| at 12 mo. | −.03 (.03) | −1.00 | .316 | .02 (.06) | .27 | .784 | .02 (.04) | .53 | .596 | −.13 (.06) | −2.04 | .042 | −.15 (.10) | −1.56 | .119 |
| Age | .00 (.00) | 2.01 | .044 | .00 (.00) | .98 | .326 | .00 (.00) | 2.45 | .014 | .00 (.00) | 1.81 | .071 | .00 (.00) | −.84 | .402 |
| BMI | .00 (.00) | −1.35 | .178 | .00 (.00) | .28 | .776 | .00 (.00) | −.09 | .932 | .001 (.00) | 1.56 | .119 | .02 (.01) | 2.51 | .012 |
| Income (> 35k vs. <35k) | .01 (.02) | −.32 | .747 | −.03 (.06) | −.55 | .582 | −.01 (.04) | −.20 | .838 | −.09 (.06) | −1.54 | .123 | −.04 (.09) | −.38 | .706 |
| Race (White vs. Black/Other) | .02 (.02) | 1.10 | .273 | −.06 (.05) | −1.24 | .214 | .05 (.04) | 1.24 | .216 | −.02 (.05) | −.46 | .648 | −.12 (.08) | −1.36 | .173 |
| Metastasis (yes vs. no) | −.03 (.02) | −1.35 | .178 | .07 (.05) | 1.43 | .154 | −.01 (.04) | −.40 | .692 | .05 (.05) | 1.07 | .286 | −.09 (.08) | −1.04 | .300 |
| ADT (yes vs. no) | .03 (.02) | 1.68 | .094 | −.02 (.04) | −.50 | .616 | −.01 (.03) | −.32 | .752 | −.02 (.05) | −.32 | .750 | −.06 (.08) | −.68 | .496 |
| Radiation (yes vs. no) | −.00 (.01) | −.06 | .951 | .00 (.03) | .10 | .919 | .03 (.02) | 1.31 | .192 | .11 (.04) | 2.74 | .006 | .06 (.06) | .92 | .355 |
| Chemotherapy (yes vs. no) | −.09 (.03) | −2.87 | .004 | −.02 (.07) | −.27 | .790 | −.05 (.04) | −1.22 | .223 | −.12 (.09) | −1.39 | .164 | .09 (.13) | .69 | .493 |
| Prostatectomy (yes vs. no) | −.01 (.02) | −.27 | .789 | .04 (.05) | .65 | .518 | .05 (.04) | 1.10 | .273 | −.06 (.06) | −1.14 | .254 | −.27 (.09) | −2.91 | .004 |
| Years since diagnosis | .00 (.00) | 1.00 | .317 | .00 (.00) | −.46 | .649 | .00 (.00) | −1.44 | .149 | .00 (.00) | −.30 | .767 | .00 (.01) | −.16 | .875 |
| Charlson Comorbidities Index | .01 (.01) | 1.47 | .140 | .03 (.02) | 1.64 | .101 | .01 (.01) | .51 | .611 | .04 (.02) | 2.57 | .010 | .04 (.03) | 1.25 | .213 |
| Time from baseline to intervention completion | .01 (.01) | .89 | .372 | .00 (.02) | .13 | .899 | .00 (.02) | .25 | .806 | .01 (.02) | .61 | .539 | −.02 (.04) | −.50 | .617 |
Note. Reference categories in binary variables are listed second. CBSM = Cognitive Behavioral Stress Management; HP = Health Promotion; SD = standard deviation; ADT androgen deprivation therapy; BMI = body mass index; Coef. = coefficient; SE = standard error.