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. 2022 Feb 22;2022:3723567. doi: 10.1155/2022/3723567

Figure 6.

Figure 6

FA inhibits DA neuron degeneration and ROS levels and enhances the food-sensing behavior in 6-OHDA-induced BZ555 C. elegans via autophagy induction. (a) 6-OHDA-induced BZ555 worms fed with HT115 bacteria or RNAi bacteria of lgg-1, vps-34, or unc-51 genes were treated with or without FA (50 μM) or L-Dopa (2 mM) for 72 h. Representative images of BZ555 worms with GFP signals in DA neurons were captured by using a fluorescence microscope. Scale bars: 25 μm. (b) The bar chart indicates the relative intensity of GFP, which represents the content of DA neuron in BZ555 worms. (c) The bar chart indicates the ROS levels of BZ555 worms after feeding with the RNAi bacteria of lgg-1, vps-34, or unc-51 in the presence or absence of FA (50 μM) or L-Dopa (2 mM). (d) The bar chart indicates the relative slowing rate (%) of BZ555 worms. Data were collected from at least 20 worms and expressed as the mean ± SD. nsp > 0.05, ∗∗p ≤ 0.01, and ∗∗∗p ≤ 0.001.