Table 2.
Incidence rates of clinical events
| Variable | Total (N = 32 275) | No OAC (n = 2445) | Warfarin (n = 8233) | DOAC (n = 21 585) |
|---|---|---|---|---|
|
Event number Incidence rate/ 100 person-years (95% CI) |
||||
| Stroke/SEE |
970 1.62 (1.52–1.73) |
88 2.00 (1.58–2.41) |
298 1.98 (1.75–2.20) |
584 1.45 (1.33–1.57) |
| Stroke |
945 1.58 (1.48–1.68) |
86 1.95 (1.54–2.36) |
287 1.90 (1.68–2.13) |
572 1.42 (1.31–1.54) |
| Ischaemic stroke |
743 1.24 (1.15–1.33) |
77 1.74 (1.35–2.13) |
227 1.50 (1.31–1.70) |
439 1.09 (0.99–1.19) |
| Haemorrhagic stroke |
201 0.33 (0.29–0.38) |
10 0.22 (0.09–0.36) |
60 0.39 (0.29–0.49) |
131 0.32 (0.27–0.38) |
| SEE |
28 0.05 (0.03–0.06) |
2 0.04 (−0.02–0.11) |
13 0.09 (0.04–0.13) |
13 0.03 (0.01–0.05) |
| Major bleeding |
645 1.08 (0.99–1.16) |
40 0.90 (0.62–1.18) |
216 1.43 (1.24–1.62) |
389 0.96 (0.87–1.06) |
| All bleeding |
2557 4.40 (4.23–4.57) |
116 2.65 (2.17–3.14) |
749 5.12 (4.76–5.49) |
1690 4.32 (4.11–4.53) |
| ICH |
453 0.75 (0.68–0.82) |
27 0.61 (0.38–0.83) |
156 1.03 (0.87–1.19) |
270 0.67 (0.59–0.75) |
| GI bleeding |
1139 1.92 (1.81–2.03) |
59 1.34 (1.00–1.68) |
316 2.11 (1.88–2.34) |
763 1.91 (1.78–2.05) |
| Cardiovascular disease |
3417 5.91 (5.71–6.11) |
259 6.03 (5.29–6.76) |
1140 7.92 (7.46–8.38) |
2018 5.16 (4.94–5.39) |
| Cardiovascular death |
654 1.08 (1.00–1.17) |
73 1.63 (1.26–2.01) |
231 1.51 (1.32–1.71) |
350 0.86 (0.77–0.95) |
| All-cause death |
2242 3.71 (3.56–3.87) |
235 5.26 (4.58–5.93) |
728 4.77 (4.43–5.12) |
1278 3.14 (2.97–3.32) |
| Net clinical outcomea |
3273 5.51 (5.32–5.70) |
313 7.13 (6.34–7.92) |
1034 6.91 (6.49–7.33) |
1925 4.81 (4.59–5.02) |
DOAC, direct oral anticoagulant; GI, gastrointestinal; ICH, intracranial haemorrhage; OAC, oral anticoagulant; SEE, systemic embolic events.
Stroke/SEE/major bleeding/all-cause death.