Table 2.
Wald χ2, P-values, and hazard ratios for components of the GARFIELD-AF all-cause mortality model
| All-cause mortality model | χ 2 | P-value | Hazard ratio (95% CI) |
|---|---|---|---|
| Agea | 956 | <0.0001 | |
| Up to 65 years | 1.17 (1.11–1.23) | ||
| 65 years or older | 1.38 (1.35–1.42) | ||
| Congestive heart failure | 403 | <0.0001 | 2.00 (1.87–2.14) |
| Ethnicity (ref.: Caucasian) | 197 | <0.0001 | |
| Hispanic/Latino | 1.17 (1.04–1.32) | ||
| Asian | 0.54 (0.49–0.60) | ||
| Afro-Caribbean/Mixed/Other | 1.46 (1.20–1.77) | ||
| Diastolic blood pressure (up to 80 mmHg)a | 100 | <0.0001 | 0.91 (0.89–0.93) |
| Weight (up to 75 kg)a | 98 | <0.0001 | 0.90 (0.88–0.92) |
| Pulse (up to 120 b.p.m.)a | 96 | <0.0001 | 1.04 (1.03–1.05) |
| Moderate-to-severe CKD | 89 | <0.0001 | 1.46 (1.35–1.58) |
| Treatment (ref.: no OAC) | 89 | <0.0001 | |
| NOAC | 0.66 (0.61–0.72) | ||
| VKA | 0.83 (0.77–0.90) | ||
| Vascular disease | 74 | <0.0001 | 1.36 (1.27–1.46) |
| Female sex | 71 | <0.0001 | 0.74 (0.69–0.79) |
| Diabetes | 55 | <0.0001 | 1.32 (1.23–1.43) |
| Dementia | 40 | <0.0001 | 1.63 (1.40–1.90) |
| Current smoker | 36 | <0.0001 | 1.41 (1.26–1.58) |
| History of bleeding | 28 | <0.0001 | 1.47 (1.27–1.70) |
| Prior stroke | 26 | <0.0001 | 1.31 (1.18–1.45) |
CI, confidence interval; CKD, chronic kidney disease; NOAC, non-VKA oral anticoagulant; OAC, oral anticoagulation; VKA, vitamin K antagonist.
a
Hazard ratios with 95% CIs are based on incremental units of ‘5’.