Table 3.
Association of genotype of studied genetic loci with gender, smoking status, co-morbidities and diagnosis based on AREDS criteria: There was a significant association between genotype and some studied variables. ADAMSTS9 genotype aas associated with AREDS criteria. IER-3 genotype was associated with the co-morbidities, and SLC16A8 genotype was associated with gender in AMD patients
| Parameters | ADAMTS9 | APOE | B3GALTl | IER-3 | |||||||||||||
| TT | CC | CT | P | AA | AG | GG | P | TT | CT | CC | P | AA | AG | GG | P | ||
| Gender | Male | 15 | 3 | 7 | 0.93 | 25 | 3 | 0.45 | 12 | 3 | 10 | 0.08 | 4 | 18 | 0.53 | ||
| Female | 10 | 2 | 6 | 20 | 1 | 16 | 0 | 5 | 5 | 14 | |||||||
| Smoking | Smoker | 7 | 3 | 3 | 0.29 | 11 | 3 | 0.03 | 6 | 1 | 5 | 0.66 | 2 | 9 | 0.72 | ||
| Non-smoker | 18 | 2 | 10 | 34 | 1 | 0 | 0 | 0 | 7 | 23 | |||||||
| Co-morbidity | Absent | 6 | 0 | 5 | 0.24 | 11 | 1 | 0.98 | 6 | 0 | 4 | 6 | 8 | 0.02 | |||
| Present | 19 | 5 | 8 | 34 | 3 | 22 | 3 | 11 | 3 | 24 | |||||||
| AREDS | Early | 0 | 1 | 0 | 0.08 | 0 | 1 | 0.002 | 1 | 0 | 0 | 0.59 | 0 | 0 | |||
| Intermediate | 4 | 1 | 3 | 8 | 0 | 6 | 1 | 3 | 2 | 8 | |||||||
| Advanced | 21 | 3 | 10 | 37 | 3 | 21 | 2 | 12 | 7 | 24 | |||||||
| Parameters | SLC16A8 | HTRA1 | LIPC | TIMP-3 | |||||||||||||
| Gender | Male | CC | TT | CT | P | GG | AA | AG | P | GG | CC | CG | P | CC | GG | GC | P |
| Female | 19 | 1 | 5 | 0.02 | 4 | 12 | 11 | 0.91 | 18 | 3 | 8 | 0.07 | 25 | 0 | 5 | 0.52 | |
| Smoking | Smoker | 7 | 1 | 11 | 3 | 10 | 7 | 9 | 1 | 14 | 16 | 0 | 5 | ||||
| Non-smoker | 5 | 1 | 4 | 0.584 | 3 | 3 | 6 | 0.19 | 6 | 3 | 5 | 0.07 | 8 | 0 | 4 | 0.17 | |
| Co-morbidty | Absent | 21 | 1 | 12 | 4 | 19 | 12 | 21 | 1 | 17 | 33 | 0 | 6 | ||||
| Present | 7 | 0 | 3 | 0.60 | 1 | 4 | 5 | 0.612 | 7 | 2 | 5 | 0.52 | 10 | 0 | 5 | 0.11 | |
| AREDS | Early | 19 | 2 | 13 | 6 | 18 | 12 | 20 | 2 | 17 | 31 | 0 | 5 | ||||
| Intermediate | 0 | 0 | 0 | 0.47 | 1 | 0 | 0 | 0.08 | 1 | 0 | 0 | 0.47 | 1 | 0 | 0 | 0.697 | |
| Advanced | 4 | 1 | 3 | 1 | 5 | 1 | 7 | 1 | 2 | 8 | 0 | 3 | |||||
| 22 | 1 | 13 | 5 | 17 | 17 | 19 | 3 | 20 | 32 | 0 | 7 | ||||||
Abbreviations: AREDS, age-related eye disease study; ADAMTS9, a disintegrin and metalloproteinase with thrombospondin motifs 9; APOE, apolipoprotein E, B3GALTL, Beta-1,3-glucosyltransferase; IER-3, immediate early response 3, SLC16A8, solute carrier family 16 member 8; HTRA1, high-temperature requirement A serine peptidase 1; LIPC, lipase C, hepatic type; TIMP-3, tissue inhibitor of metalloproteinases 3.