Fig. 4.
Cotranplantation of NT-3-SCs with TrkC-MSCs could promote the recovery of paralyzed limb motor function in canine with complete SCI. (A) Schematic illustration of the construction method of MSC-derived neural network tissue in the 3D gelatin sponge scaffold. (B-D) TrkC-MSCs co-culturing with NT-3-SCs for 14 d enabled the neural lineage differentiation in vitro. (E-H) Exploration of the pelvic limb motor functional recovery from the 1st month after SCI. (Reproduced from [80], Copyright 2018 Elsevier B.V.).