Table 1.
Characteristics of Diffuse Large B-Cell Lymphoma According to GLUT-3 Expression
| Characteristic | N (%) n=91 | GLUT3 | P–value | |
|---|---|---|---|---|
| High (≥10%) | Low (<10%) | |||
| Sex | ||||
| Male | 56 (61.5) | 35 (55.6) | 21 (75) | 0.078 |
| Female | 35 (38.5) | 28 (44.4) | 7 (25) | |
| Age | ||||
| ≤60 years | 53 (58.2) | 37 (58.7) | 16 (57.1) | 0.887 |
| >60 years | 38 (41.8) | 26 (41.3) | 12 (42.9) | |
| Presence of B symptoms | ||||
| No | 78 (85.7) | 57 (90.5) | 21 (75) | 0.052 |
| Yes | 13 (14.3) | 6 (9.5) | 7 (25) | |
| Ann Arbor stage | ||||
| I/II | 61 (67) | 42 (66.7) | 19 (67.9) | 0.911 |
| III/IV | 30 (33) | 21 (33.3) | 9 (32.1) | |
| Performance status | ||||
| ECOG 0–1 | 84 (92.3) | 58 (92.1) | 26 (92.9) | 0.896 |
| ECOG ≥2 | 7 (7.7) | 5 (7.9) | 2 (7.1) | |
| LDH level | ||||
| <246 U/L | 28 (31) | 12 (23) | 16 (42) | 0.047 |
| ≥246 U/L | 63 (69) | 41 (77) | 22 (58) | |
| Number of extranodal sites | ||||
| 0–1 | 85 (93.4) | 58 (92.1) | 27 (96.4) | 0.685 |
| 2–3 | 5 (5.5) | 4 (6.3) | 1 (3.6) | |
| 4–5 | 1 (1.1) | 1 (1.6) | 0 (0) | |
| Bone marrow involvement | ||||
| Absence | 84 (92.3) | 57 (90.5) | 27 (96.4) | 0.325 |
| Presence | 7 (7.7) | 6 (9.5) | 1 (3.6) | |
| Bulky disease | ||||
| No | 70 (76.9) | 47 (74.6) | 23 (82.1) | 0.431 |
| Yes | 21 (23.1) | 16 (25.4) | 5 (17.9) | |
| Subtype | ||||
| GCB | 29 (31.9) | 20 (31.7) | 9 (32.1) | 0.970 |
| Non-GCB | 62 (68.1) | 43 (67.9) | 19 (67.9) | |
| IPI | ||||
| 0–1 | 72 (79.1) | 48 (76.2) | 24 (85.7) | 0.526 |
| 2–3 | 18 (19.8) | 14 (22.2) | 4 (14.3) | |
| 4–5 | 1 (1.1) | 1 (1.6) | 0 (0) | |
| Recurrence | ||||
| Yes | 48 (52.7) | 38 (60.3) | 10 (35.7) | 0.030 |
| No | 43 (47.3) | 25 (39.7) | 18 (64.3) | |
| Ki-67 | ||||
| <80% | 43 (47.3) | 24 (38.1) | 19 (67.9) | 0.009 |
| ≥80% | 48 (52.7) | 39 (61.9) | 9 (32.1) | |
Abbreviations: GLUT-3, glucose transporter 3; GCB, germinal center B cell; IPI, International Prognostic Index.