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. 2022 Feb 16;13:812317. doi: 10.3389/fimmu.2022.812317

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Copyright © 2022 Leffler, Trend, Ward, Grau, Hawke, Byrne, Kermode, French and Hart

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A, B) Non-parametric correlation between plasma levels of the SCFAs; Butyrate, Propionate and Acetate with abundance of IgA⁺ MBC or IgA⁺ MBC subsets (A) as well as display of raw data for the two strongest correlations (B) identified in (A). Correlations are visualized using a linear fit and 95% CI. Data are displayed as mean correlation ± 95% CI (A) or for each participant (n = 12) in (B). Significance of correlation was calculated using Spearman non-parametric test displayed as specific p-value.