Table 3.
Univariable and multivariable Cox proportional hazards analysis for histologic lesions and phenotypes, according to the broadness of pretransplant non-HLA antibodies in the absence of HLA-DSA (N=774).
| Predictor: Broadness of pretransplant non-HLA antibodies (per 10 antibodies increment) | ||||||
|---|---|---|---|---|---|---|
| Histologic outcome of the model | Univariable analysis | Multivariable analysis | ||||
| HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Histologic phenotypes (events) | ||||||
| ABMRh (125) | 1.23 | 1.10 – 1.37 | 0.0004 | 1.21 | 1.08 – 1.36 | 0.001 |
| ABMR 2019 (29) | 1.29 | 1.03 – 1.61 | 0.03 | 1.30 | 1.04 – 1.63 | 0.02 |
| TCMR (218) | 1.01 | 0.91 – 1.12 | 0.87 | 1.00 | 0.89 – 1.11 | 0.92 |
| TCMR and borderline (330) | 1.04 | 0.95 – 1.13 | 0.39 | 1.02 | 0.94 – 1.11 | 0.64 |
| Microvascular inflammation score ≥2 (148) | 1.15 | 1.03 – 1.28 | 0.01 | 1.13 | 1.01 – 1.26 | 0.04 |
| IFTA score 2 (425) | 1.02 | 0.94 – 1.11 | 0.64 | 1.02 | 0.94 – 1.11 | 0.64 |
| Individual lesions (events) | ||||||
| Glomerulitis (g) score> 0 (203) | 1.09 | 0.99 – 1.21 | 0.08 | 1.07 | 0.96 – 1.18 | 0.23 |
| Glomerulitis (g) score> 1 (70) | 1.24 | 1.07 – 1.44 | 0.005 | 1.19 | 1.02 – 1.39 | 0.03 |
| Peritubular capillaritis (ptc) score> 0 (214) | 1.03 | 0.93 – 1.14 | 0.61 | 1.02 | 0.92 – 1.13 | 0.73 |
| Peritubular capillaritis (ptc) score> 1 (95) | 1.09 | 0.94 – 1.26 | 0.25 | 1.08 | 0.93 – 1.25 | 0.31 |
| Endarteritis (v) score> 0 (139) | 1.07 | 0.94 – 1.21 | 0.31 | 1.04 | 0.92 – 1.18 | 0.54 |
| Endarteritis (v) score> 1 (20) | 1.15 | 0.85 – 1.54 | 0.37 | 1.11 | 0.82 – 1.50 | 0.49 |
| c4d score> 0 (262) | 1.04 | 0.95 – 1.14 | 0.46 | 1.03 | 0.94 – 1.13 | 0.51 |
| c4d score> 1 (50) | 1.19 | 0.99 – 1.43 | 0.06 | 1.19 | 0.98 – 1.43 | 0.07 |
| Interstitial inflammation (i) score> 0 (317) | 1.02 | 0.94 – 1.11 | 0.67 | 1.00 | 0.92 – 1.10 | 0.96 |
| Interstitial inflammation (i) score> 1 (184) | 1.04 | 0.93 – 1.16 | 0.54 | 1.02 | 0.91 – 1.14 | 0.75 |
| Tubulitis (t) score> 0 (531) | 1.01 | 0.94 – 1.08 | 0.86 | 0.98 | 0.91 – 1.05 | 0.56 |
| Tubulitis (t) score> 1 (262) | 1.05 | 0.96 – 1.15 | 0.27 | 1.02 | 0.93 – 1.12 | 0.72 |
| Chronic allograft glomerulopathy (cg) score>0 (70) | 0.88 | 0.70 – 1.10 | 0.24 | 0.83 | 0.66 – 1.06 | 0.14 |
| Chronic allograft glomerulopathy (cg) score>1 (25) | 0.89 | 0.62 – 1.28 | 0.53 | 0.86 | 0.59 – 1.27 | 0.46 |
| Arteriolar hyalinosis (ah) score> 1 (253) | 1.02 | 0.92 – 1.12 | 0.74 | 1.00 | 0.91 – 1.11 | 0.94 |
| Interstitial fibrosis (ci) score> 1 (361) | 1.01 | 0.93 – 1.10 | 0.76 | 1.01 | 0.93 – 1.10 | 0.77 |
| Tubular atrophy (ct) score> 1 (296) | 0.99 | 0.91 – 1.09 | 0.89 | 1.00 | 0.91 – 1.10 | 0.94 |
| Vascular intimal thickening (cv) score> 1 (350) | 1.02 | 0.94 – 1.11 | 0.69 | 1.00 | 0.92 – 1.09 | 0.93 |
| Mesangial matrix expansion (mm) score> 0 (183) | 1.07 | 0.96 – 1.20 | 0.21 | 1.03 | 0.92 – 1.16 | 0.58 |
All multivariable Cox models were adjusted for anti-HLA antibodies, HLA-A, -B-DR, -DQ antigen mismatches, repeated transplantation, deceased donation, recipient sex, recipient and donor age and induction therapy.
C4d, complement 4d deposition.