Table 4.

Univariable and multivariable Cox proportional hazards analysis of death-censored graft failure, according to the presence of pretransplant non-HLA antibodies in the absence of HLA-DSA (N=774).

Pretransplant non-HLA antibodies	No. of patients	No. of events	HR	95% CI	p-value
Univariable analysis
Broadness of non-HLA antibodies
Total positivity for non-HLA antibodies (per 10)	774	110	0.88	0.69	1.11
Quartiles for non-HLA abs positivity	774
Quartile 1 (0 - 3)	167	31	1	–	–
Quartile 2 (4 - 7)	228	28	0.89	0.45	1.77
Quartile 3 (8 - 14)	174	24	0.84	0.41	1.73
Quartile 4 (15 - 63)	205	27	0.53	0.24	1.16
Strength of non-HLA antibodies
Total ratios of non-HLA antibodies (per 10)	774	110	0.98	0.92 – 1.04	0.47
Quartiles of non-HLA abs strength	774
Quartile 1 (0.0 – 9.7)	196	29	1	–	–
Quartile 2 (9.8 – 19.5)	192	28	0.58	0.35 – 0.96	0.03
Quartile 3 (19.6 – 39.5)	191	29	0.70	0.41 – 1.19	0.19
Quartile 4 (39.8 – 223.6)	196	24	0.67	0.40 – 1.12	0.13
Multivariable analysis
Broadness of non-HLA antibodies
Model 1: Total positivity (per 10)	774	110	0.84	0.65	1.09
Model 2: Non-HLA antibodies positivity	774	110
Quartile 1 (0 - 3)	167	31	1	–	–
Quartile 2 (4 - 7)	228	28	0.81	0.41	1.63
Quartile 3 (8 - 14)	174	24	0.73	0.35	1.53
Quartile 4 (15 - 63)	205	27	0.43	0.19	0.99
Strength of non-HLA antibodies
Model 3: Total ratios of non-HLA abs (per 10)	774	110	0.97	0.91 – 1.03	0.31
Model 4: Non-HLA antibody strength	774	110
Quartile 1 (0.0 – 9.7)	196	29	1	–	–
Quartile 2 (9.8 – 19.5)	192	28	0.57	0.34 – 0.96	0.03
Quartile 3 (19.6 – 39.5)	191	29	0.65	0.65 – 1.11	0.11
Quartile 4 (39.8 – 223.6)	196	24	0.63	0.37 – 1.07	0.08

All multivariable Cox models were adjusted for anti-HLA antibodies, HLA-A,-B,-DR,-DQ antigen mismatches, repeated transplantation, deceased donation, recipient sex, recipient and donor age and induction therapy.