. 2022 Feb 16;10:811044. doi: 10.3389/fpubh.2022.811044

Table 4.

Trend analysis of age-standardized mortality for prostate cancer from 2000 to 2019.

Country	AAPC	Range	Trend1			Trend2			Trend3			Trend4
			Period	EAPC	Range	Period	EAPC	Range	Period	EAPC	Range	Period	EAPC	Range
Albania	0.05	−0.47–0.57	2000–04	0.81	−0.67–2.32	2004–08	−2.72^*	−4.86 to −0.54	2008–19	0.8^*	0.54–1.06
Argentina	−0.9^*	−1.01 to −0.78	2000–03	0.09	−0.34–0.52	2003–07	−0.9^*	−1.31 to −0.48	2007–14	−1.8^*	−1.94 to −1.67	2014–19	−0.2^*	−0.37 to −0.02
Armenia	1^*	0.76–1.25	2000–16	1.32^*	1.18–1.46	2016–19	−0.65	−2.14–0.87
Australia	−1.1^*	−1.2 to −0.99	2000–03	0.38	−0.06–0.82	2003–08	−1.35^*	−1.61 to −1.09	2008–14	−2.99^*	−3.17 to −2.82	2014–19	0.59^*	0.42–0.76
Austria	−1.73^*	−1.87 to −1.6	2000–04	−3.09^*	−3.55 to −2.61	2004–14	−1.77^*	−1.91 to −1.64	2014–19	−0.55^*	−0.88 to −0.23
Azerbaijan	0.43^*	0.29–0.58	2000–03	2.83^*	2.12–3.55	2003–17	0.27^*	0.21–0.33	2017–19	−1.94^*	−2.97 to −0.89
Bahamas	−0.16	−0.9–0.58	2000–02	3.3	−1.19–8	2002–05	−2.58	−6.6–1.61	2005–19	−0.12	−0.29–0.05
Bahrain	−0.26	−1–0.49	2000–04	6.02^*	2.91–9.22	2004–14	−3.04^*	−3.75 to −2.32	2014–19	0.51	−0.94–1.98
Barbados	−0.17	−0.51–0.16	2000–04	1.38^*	0.53–2.24	2004–12	−2.61^*	−2.94 to −2.27	2012–17	0.17	−0.61–0.95	2017–19	5.91^*	3.6–8.27
Belarus	0.26	−0.03–0.54	2000–10	0.9^*	0.48–1.32	2010–19	−0.45	−0.91–0.01
Belgium	−1.75^*	−1.97 to −1.53	2000–07	−1.61^*	−1.78 to −1.44	2007–13	−3.65^*	−3.93 to −3.36	2013–16	−1.17	−2.47–0.15	2016–19	1.24^*	0.6–1.88
Belize	−0.91^*	−1.35 to −0.48	2000–03	−2.27^*	−3.5 to −1.04	2003–06	−0.5	−2.9–1.95	2006–10	−3.28^*	−4.41 to −2.13	2010–19	0.48^*	0.29–0.66
Brazil	−0.98^*	−1.14 to −0.83	2000–04	0.25	−0.18–0.68	2004–09	−1.1^*	−1.49 to −0.71	2009–14	−2^*	−2.37 to −1.63	2014–19	−0.82^*	−1.06 to −0.57
Brunei Darussalam	1.89^*	1.47–2.31	2000–13	3.43^*	3–3.85	2013–19	−1.35^*	−2.43 to −0.26
Bulgaria	2.17^*	1.94–2.41	2000–08	4.68^*	4.38–4.99	2008–13	1.87^*	1.13–2.61	2013–19	−0.84^*	−1.21 to −0.46
Canada	−2.19^*	−2.65 to −1.74	2000–04	−2^*	−2.86 to −1.14	2004–12	−4.63^*	−4.99 to −4.27	2012–15	−1.06	−3.81–1.77	2015–19	1.79^*	0.95–2.63
Chile	−0.52^*	−0.78 to −0.27	2000–12	−0.33^*	−0.47 to −0.19	2012–16	−1.55^*	−2.58 to −0.51	2016–19	0.1	−0.89–1.1
China	−0.59^*	−0.69 to −0.5	2000–08	−0.82^*	−1.01 to −0.62	2008–19	−0.43^*	−0.53 to −0.33
Colombia	−1.31^*	−2.65–0.05	2000–02	3.77	−4.23–12.43	2002–05	−5.74	−12.68–1.75	2005–15	−1.87^*	−2.54 to −1.21	2015–19	1.05	−1.03–3.19
Costa Rica	−0.19	−0.38–0.01	2000–19	−0.19	−0.38–0.01
Croatia	0.4^*	0.14–0.66	2000–05	2.38^*	1.65–3.12	2005–15	−0.04	−0.3–0.21	2015–19	−0.94^*	−1.75 to −0.12
Cuba	0.54^*	0.39–0.69	2000–09	0.8^*	0.53–1.07	2009–19	0.3^*	0.11–0.5
Czechia	−0.97^*	−1.16 to −0.78	2000–04	0.33	−0.2–0.87	2004–10	−1.17^*	−1.52 to −0.82	2010–15	−2.3^*	−2.77 to −1.83	2015–19	−0.28	−0.75–0.19
Denmark	−0.78^*	−0.94 to −0.62	2000–05	1.3^*	1.03–1.58	2005–09	−0.77^*	−1.34 to −0.19	2009–14	−3.12^*	−3.47 to −2.77	2014–19	−0.48^*	−0.73 to −0.24
Dominican Republic	−0.5	−1.04–0.05	2000–05	2.16^*	1.36–2.96	2005–08	−5.12^*	−8.22 to −1.92	2008–15	0.91^*	0.37–1.45	2015–19	−2.65^*	−3.57 to −1.72
Ecuador	0.14	−0.02–0.31	2000–06	1.88^*	1.53–2.22	2006–12	−0.23	−0.62–0.15	2012–19	−1^*	−1.2 to −0.79
El Salvador	−0.04	−0.86–0.78	2000–02	−2.21	−7.76–3.68	2002–06	2.81^*	0.01–5.69	2006–13	−2.65^*	−3.52 to −1.76	2013–19	1.91^*	1.06–2.78
Estonia	0.48^*	0.24–0.72	2000–06	2.55^*	2.04–3.07	2006–15	0.11	−0.17–0.4	2015–19	−1.74^*	−2.51 to −0.97
Finland	−1.44^*	−1.6 to −1.28	2000–02	−1.05	−2.27–0.18	2002–08	−3.07^*	−3.33 to −2.8	2008–14	−1.3^*	−1.56 to −1.04	2014–19	0.22	−0.02–0.47
France	−2.19^*	−2.39 to −2	2000–03	−2.02^*	−2.58 to −1.46	2003–11	−3.75^*	−3.9 to −3.6	2011–14	−3.02^*	−4.18 to −1.84	2014–19	0.75^*	0.5–1.01
Georgia	3.63^*	3.19–4.07	2000–05	10.27^*	8.97–11.6	2005–12	3.02^*	2.24–3.82	2012–19	−0.3	−0.87–0.28
Germany	−1.41^*	−1.53 to −1.28	2000–08	−1.97^*	−2.04 to −1.89	2008–11	−2.31^*	−2.99 to −1.62	2011–15	−1.08^*	−1.43 to −0.73	2015–19	0.08	−0.14–0.3
Greece	−1.3^*	−1.49 to −1.11	2000–03	−1.03	−1.74 to −0.31	2003–11	−3.16^*	−3.35 to −2.97	2011–16	−0.16	−0.64–0.31	2016–19	1.58^*	0.85–2.32
Guatemala	−0.42^*	−0.7 to −0.13	2000–05	1.32^*	0.86–1.79	2005–14	−1.1^*	−1.28 to −0.91	2014–17	−2.02^*	−3.56 to −0.46	2017–19	0.79	−0.7–2.31
Guyana	−0.33	−0.65–0	2000–04	−1.38^*	−2.05 to −0.71	2004–11	−0.14	−0.48–0.21	2011–14	1.13	−0.82–3.11	2014–19	−0.61^*	−1.02 to −0.19
Hungary	−1.08^*	−1.23 to −0.93	2000–13	−1.64^*	−1.77 to −1.51	2013–19	0.13	−0.3–0.57
Iceland	−1.53^*	−1.94 to −1.11	2000–11	−0.81^*	−1 to −0.62	2011–14	−5.3^*	−7.83 to −2.7	2014–19	−0.81^*	−1.39 to −0.21
Ireland	−1.85^*	−2.05 to −1.64	2000–04	−1.69^*	−2.08 to −1.3	2004–14	−2.73^*	−2.84 to −2.62	2014–17	−0.64	−1.8–0.55	2017–19	0.49	−0.63–1.63
Israel	−1.99^*	−2.51 to −1.46	2000–09	−1.93^*	−2.2 to −1.66	2009–13	−4.47^*	−5.89 to −3.03	2013–16	−1.32	−4.19–1.63	2016–19	0.54	−0.84–1.95
Italy	−1.54^*	−1.63 to −1.45	2000–03	−1.61^*	−2.08 to −1.14	2003–14	−2.25^*	−2.32 to −2.18	2014–19	0.07	−0.14–0.28
Jamaica	0.23	−1.07–1.55	2000–06	−0.49	−1.85–0.89	2006–09	8.46^*	0.79–16.72	2009–13	−5.07^*	−8.5 to −1.51	2013–19	0.64	−0.56–1.85
Japan	−0.68^*	−0.81 to −0.54	2000–05	−0.38^*	−0.57 to −0.19	2005–08	−1.47^*	−2.24 to −0.68	2008–17	−0.79^*	−0.87 to −0.71	2017–19	0.28	−0.45–1.01
Kazakhstan	0.65^*	0.22–1.09	2000–11	1.35^*	1.19–1.5	2011–14	−0.73	−2.72–1.3	2014–17	1.24	−0.75–3.27	2017–19	−1.91^*	−3.73 to −0.06
Kuwait	0.53	−0.13–1.19	2000–08	2.12^*	1.57–2.67	2008–11	−5.23^*	−9.19 to −1.09	2011–19	1.17^*	0.76–1.58
Kyrgyzstan	−0.95	−1.97–0.08	2000–03	−4.44^*	−7.26 to −1.54	2003–13	−1^*	−1.59 to −0.42	2013–16	3.29	−2.74–9.69	2016–19	−1.35	−4.12–1.51
Latvia	0.97^*	0.7–1.23	2000–06	5.14^*	4.56–5.72	2006–14	−0.28	−0.67–0.1	2014–19	−1.89^*	−2.53 to −1.26
Lithuania	0.52^*	0.14–0.91	2000–07	5.43^*	4.91–5.94	2007–11	−3.03^*	−4.62 to −1.42	2011–19	−1.83^*	−2.2 to −1.46
Luxembourg	−2.21^*	−2.54 to −1.88	2000–02	−4.37^*	−6.55 to −2.14	2002–06	−1.92^*	−3.05 to −0.77	2006–15	−3.09^*	−3.33 to −2.85	2015–19	0.61	−0.07–1.29
Malta	−1.76^*	−2.17 to −1.35	2000–13	−1.62^*	−1.77 to −1.48	2013–16	−4.42^*	−6.86 to −1.92	2016–19	0.35	−0.89–1.6
Mauritius	−0.68^*	−0.83 to −0.53	2000–19	−0.68^*	−0.83 to −0.53
Mexico	−0.34^*	−0.52 to −0.16	2000–16	−0.51^*	−0.61 to −0.41	2016–19	0.59	−0.53–1.71
The Netherlands	−1.06^*	−1.34 to −0.77	2000–03	0.16	−0.7–1.03	2003–06	−3.6^*	−5.24 to −1.93	2006–13	−1.54^*	−1.82 to −1.26	2013–19	0.19	−0.07–0.45
New Zealand	−1.6^*	−1.92 to −1.28	2000–05	−3.38^*	−3.93 to −2.83	2005–12	−2.08^*	−2.5 to −1.66	2012–17	−0.44	−1.18–0.32	2017–19	1.74	−0.48–4.01
Nicaragua	0.26	−0.02–0.54	2000–05	1.77^*	1.22–2.32	2005–12	−0.27^*	−0.63–0.09	2012–16	−1.78^*	−2.76 to −0.79	2016–19	1.79^*	0.84–2.75
North Macedonia	0.72^*	0.53–0.9	2000–07	1.4^*	1.1–1.71	2007–16	0.81^*	0.6–1.03	2016–19	−1.16^*	−2.04 to −0.27
Norway	−1.3^*	−1.44 to −1.16	2000–07	−1.06^*	−1.23 to −0.88	2007–17	−1.7^*	−1.82 to −1.59	2017–19	−0.16	−1.37–1.06
Panama	−0.81^*	−1.1 to −0.52	2000–03	0.9	−0.71–2.54	2003–11	−1.48^*	−1.86 to −1.09	2011–19	−0.77^*	−1.05 to −0.49
Paraguay	0.1	−0.19–0.39	2000–04	1.59^*	0.81–2.37	2004–10	−0.51^*	−1 to −0.02	2010–14	−1.21^*	−2.23 to −0.18	2014–19	0.69^*	0.25–1.12
Peru	−0.37^*	−0.59 to −0.16	2000–07	−0.9^*	−1.09 to −0.71	2007–10	2.83^*	1.51–4.18	2010–15	−1.62^*	−1.99 to −1.24	2015–19	−0.26	−0.61–0.1
Philippines	0.11	−0.02–0.25	2000–04	−1.47^*	−1.85 to −1.09	2004–09	0.71^*	0.35–1.07	2009–15	1.1^*	0.87–1.33	2015–19	−0.5^*	−0.79 to −0.21
Poland	−0.35^*	−0.52 to −0.17	2000–06	−0.07	−0.39–0.24	2006–11	−1.06^*	−1.61 to −0.5	2011–19	−0.11	−0.28–0.07
Portugal	−1.72^*	−1.83 to −1.62	2000–02	−3.24^*	−3.99 to −2.49	2002–07	−2.53^*	−2.77 to −2.29	2007–14	−2.11^*	−2.24 to −1.98	2014–19	0.27^*	0.1–0.44
Korea, Republic of	−0.48^*	−0.67 to −0.28	2000–08	0.63^*	0.47–0.78	2008–11	−0.31	−1.44–0.85	2011–16	−2.07^*	−2.39 to −1.74	2016–19	−0.9^*	−1.37 to −0.43
Republic of Moldova	2.6^*	2.2–3	2000–15	3.82^*	3.53–4.11	2015–19	−1.86^*	−3.54 to −0.15
Romania	0.54^*	0.27–0.8	2000–07	0.19	−0.23–0.61	2007–15	1.2^*	0.8–1.59	2015–19	−0.17	−1.02–0.69
Russian Federation	0.87^*	0.68–1.05	2000–15	1.54^*	1.41–1.67	2015–19	−1.63^*	−2.45 to −0.8
Saint Lucia	−0.17	−0.62–0.27	2000–02	0.84	−3.17–5.02	2002–11	−1.93^*	−2.34 to −1.53	2011–19	1.59^*	1.23–1.95
Serbia	0.91^*	0.45–1.36	2000–07	3.75^*	3.36–4.15	2007–11	−1.12	−2.38–0.15	2011–14	0.97	−1.53–3.55	2014–19	−1.4^*	−1.94 to −0.85
Singapore	−1.14^*	−1.36 to −0.91	2000–03	−2.71^*	−3.77 to −1.63	2003–08	−0.4	−1.05–0.26	2008–19	−1.04^*	−1.15 to −0.93
Slovakia	−0.08	−0.34–0.18	2000–04	−1.64	−2.19 to −1.08	2004–12	1.73	1.51–1.96	2012–15	−0.2	−1.69–1.32	2015–19	−1.99	−2.44 to −1.53
Slovenia	−0.58	−0.86 to −0.3	2000–10	−0.22	−0.43 to −0.01	2010–14	−2.3	−3.5 to −1.08	2014–19	0.09	−0.43–0.62
South Africa	−0.32^*	−0.48 to −0.16	2000–05	−0.82^*	−1.12 to −0.51	2005–10	1.19^*	0.78–1.61	2010–16	0.2	−0.07–0.47	2016–19	−2.99^*	−3.54 to −2.44
Spain	−1.66^*	−1.83 to −1.48	2000–07	−2.87^*	−3 to −2.73	2007–12	−2.02^*	−2.35 to −1.7	2012–15	−1.35^*	−2.37 to −0.31	2015–19	0.72^*	0.4–1.04
Sri Lanka	0.05	−0.09–0.19	2000–12	0.75^*	0.58–0.91	2012–19	−1.12^*	−1.43 to −0.82
Suriname	0.36^*	0.02–0.7	2000–02	4.01^*	1.76–6.3	2002–11	−0.82^*	−1.04 to −0.61	2011–14	2.23^*	0.41–4.1	2014–19	−0.06	−0.43–0.31
Sweden	−1.53^*	−1.64 to −1.43	2000–04	−0.86^*	−1.24 to −0.48	2004–14	−2.37^*	−2.48 to −2.26	2014–19	−0.39^*	−0.65 to −0.12
Switzerland	−1.69^*	−1.83 to −1.55	2000–13	−2.32^*	−2.37 to −2.28	2013–16	−0.59	−1.46–0.29	2016–19	−0.01	−0.43–0.41
Syrian Arab Republic	−0.13	−0.48–0.22	2000–03	−3.24^*	−4.21 to −2.26	2003–06	−0.98	−2.92–0.99	2006–10	2.19^*	1.26–3.13	2010–19	0.19^*	0.05–0.34
Tajikistan	0.75^*	0.54–0.97	2000–09	0.79^*	0.61–0.98	2009–17	1.6^*	1.35–1.85	2017–19	−2.75^*	−4.5 to −0.97
Thailand	−0.94^*	−1.16 to −0.73	2000–02	−4.09^*	−6.04 to −2.1	2002–13	−1.22^*	−1.36 to −1.08	2013–19	0.64^*	0.38–0.9
Trinidad and Tobago	−0.8^*	−1.1 to −0.5	2000–08	−0.81^*	−1.12 to −0.49	2008–12	−2.17^*	−3.5 to −0.82	2012–19	0	−0.34–0.34
Turkey	−0.72	−1.77–0.34	2000–02	13.51^*	7.43–19.94	2002–05	−0.51	−5.14–4.33	2005–08	−6.01^*	−10.42 to −1.37	2008–19	−1.71^*	−2.02 to −1.41
Turkmenistan	0.29	−0.34–0.92	2000–02	−0.54	−4.05–3.11	2002–06	2.47^*	0.77–4.21	2006–09	−2.97	−5.98–0.12	2009–19	0.58^*	0.36–0.8
Ukraine	0.23	−0.13–0.59	2000–09	−1.71^*	−2.31 to −1.12	2009–19	2.01^*	1.5–2.52
United Kingdom	−0.73^*	−0.9 to −0.56	2000–02	−0.59	−1.86–0.69	2002–08	−1.78^*	−2.06 to −1.5	2008–14	−0.53^*	−0.8 to −0.25	2014–19	0.24	−0.02–0.5
United States of America	−1.22^*	−1.38 to −1.06	2000–04	−2.71^*	−3.01 to −2.4	2004–10	−1.99^*	−2.21 to −1.77	2010–13	−1.05^*	−2 to −0.1	2013–19	0.48^*	0.33–0.63
Uruguay	−0.8^*	−1.01 to −0.59	2000–04	1.21^*	0.67–1.76	2004–09	−1.28^*	−1.8 to −0.75	2009–16	−2.16^*	−2.44 to −1.88	2016–19	0.56	−0.29–1.41
Uzbekistan	0.52^*	0.21–0.83	2000–03	3.44^*	1.42–5.49	2003–19	−0.02	−0.16–0.13
Venezuela, Bolivarian Republic of	0.17	−0.6–0.96	2000–08	2.23^*	1.13–3.34	2008–15	−3.78^*	−5.17 to −2.38	2015–19	3.23^*	0.77–5.74

p-value < 0.05.

AAPC, Average Annual Percentage Change; EAPC, Estimated Annual Percentage Change.