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. 2021 Jun 8;43(3):659–671. doi: 10.1038/s41401-021-00689-2

Fig. 1. Effect of the Epac-selective analog 8-pCPT-2′-O-Me-AMP on renal functional and morphological characteristics in db/db mice.

Fig. 1

a Epac expression was measured by Western blot assays. b Immunofluorescence staining of Epac in kidney tissues. c Body weight changes in db/m, db/db and db/db mice that received 8-pCPT-2′-O-Me-cAMP (8-O-cAMP) treatment. d Blood glucose concentrations in each group. e, f The levels of serum creatinine and urine albumin. g Renal morphological analysis was assessed by PAS (i–vi) and Masson’s trichrome staining (vii–xii). h, i Quantitative analysis of tubular and glomerular damage scores in each group (n = 5); the values are the mean ± SD; *P < 0.05 vs db/m, #P < 0.05 vs db/db mice.