Table 2.

Tumour mutation analysis (KRAS/BRAF) in metastatic colorectal cancer patients with cytoreductive surgery and HIPEC (CRS-HIPEC) (n = 174).

Parameter	mutKRAS (n = 59)		mutBRAF (n = 43)		Double wt (n = 72)		P
	n	%	n	%	n	%
Gender
Female	39	66.1	32	74.4	41	56.9	0.163
Age, median (range)	59.0	23–77	60.9	33–75	57.3	22–76	0.091
pT-stage
T1-2	0	0	1	2.4	0	0	0.686a
T3	21	38.2	23	54.8	28	43.1
T4	34	61.8	18	42.9	37	56.9
N-stage
N0	17	29.3	14	32.6	17	25.0	0.128a
N1	26	44.1	11	25.6	22	31.4
N2	16	27.6	18	41.9	31	44.3
Missing	0		0		2
Grade of tumour differentiation							0.003
Poorly	6	12.3	16	40.0	22	40.7
Moderate	40	81.6	21	52.5	31	57.4
Well	3	6.1	3	7.5	1	1.9
Not reported	10		3		18
Signet ring cells
Yes	1	2.7	5	15.6	9	20.0	0.039
No	36	97.3	27	84.4	36	80.0
Not reported	22		11		27
Tumour location 1
Right colon	18	30.5	30	69.8	25	34.7	<0.001
Left colon and rectum	41	69.5	13	30.2	47	65.3
Tumour location 2
Colon	54	91.5	43	100	61	84.7	0.012
Rectum	5	8.5	0	0	11	15.3
Peritoneal metastases
Synchronous	19	32.2	11	25.6	26	36.1	0.513
Metachronous	40	67.8	32	74.4	46	63.9
Chemoterapy earlier than CRS-HIPEC							0.024
Yes	33	55.9	31	72.1	56	77.8
No	26	44.1	12	27.9	16	22.2
CEA (µg/L)
< 5	23	39.0	24	55.8	51	71.8	0.001
>5	36	61.0	19	44.2	20	28.2
Missing					1
PCI
1–10	35	59.3	28	66.1	42	58.3	0.997a
11–20	20	33.9	12	27.9	26	36.1
>20	4	6.8	3	7.0	4	5.6
MSI	0	0	12	29.3	3	8.1	<0.001
MSS	33	100	29	70.7	34	91.9
Missing	26		2		35
mutBRAF with MSI	0	0	12	29.3	0	0	<0.001
mutBRAF with MSS	0	0	29	70.7	0	0
wtBRAF	59	100	0	0	72	100
Missing	0		2		0
Median time from peritoneal metastasis to HIPEC (months)	3	0–43	3	0–24	3	0–53	0.889
Median time from primary cancer to HIPEC (months)	13	0–69	13	0–55	10	0–81	0.995
Median DFI (months)
0	31	52.5	23	53.5	42	58.3	0.704
1–12	14	23.7	8	18.6	10	13.9
>12	14	23.7	12	27.9	20	27.8
Type of recurrence at 5 years							0.819
Local recurrence	18	30.5	13	30.2	17	23.9
Distal metastasis	20	33.9	16	37.2	26	36.6
Both	13	22.0	8	18.6	12	16.9
Alive	8	13.6	6	14.0	16	22.5

^aLinear-by-linear association.

Statistically significant p < 0.05 values are in bold.