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. 2022 Mar 2;7:65. doi: 10.1038/s41392-022-00885-4

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Presence of regeneration-promoting microglia in the adult spinal cord. a Feature plot showing average expression of different groups (MG 0/1/3) of neonatal microglia signature genes in different adult spinal cord microglia clusters. b Feature plots showing average expression of repopulation microglia signature genes in adult spinal cord microglia clusters. c UMAP visualization plot showing neonatal microglia MG 0/1/3 and adult spinal cord microglia cluster 4/7/3 merged correspondingly, in a subtype-specific manner. d Feature plots showing average expression of repopulation microglia signature genes in MG 0/1/3 (neonatal) and cluster 3/4/7 (adult). e Clustering heatmap based on Pearson’s correlation coefficient between MG 0/1/3 (neonatal) and cluster 3/4/7(adult), showing similarity between corresponding neonatal and adult microglia subtypes were 0.93, across all three subtypes. f Line chart showing temporal changes in relative contents of MG 0 (neonatal)/cluster 4 (adult), MG 1 (neonatal)/cluster 7 (adult), and MG 3 (neonatal)/cluster 3 (adult). g Temporal gene expression changes of Cd68 and P2ry12 in neonatal and adult spinal cord post-injury. h Violin plots showing Cd68 and P2ry12 expression levels in MG 0 (neonatal)/cluster 4 (adult), MG 1 (neonatal)/cluster 7 (adult), and MG 3 (neonatal)/cluster 3 (adult) (****P < 0.0001; N.S., not significant)