Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 2;10:24. doi: 10.1038/s41413-022-00186-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Sialylated TLR2 binds to Siglec15 as a Siglec15 receptor. a Identification of 318 potential Siglec15 binding proteins using the proximity labeling method followed by LC–MS/MS. The number of membrane proteins and glycoproteins is shown. b Most highly enriched glyco-membrane protein evaluated by the Mascot score, peak area and unique peptides. c Hierarchical clustering heatmap showing the expression of mouse TLR family members in BMMs, pOCs and mOCs detected by RNA-seq. d Immunoblotting (IB) for Siglec15 in whole-cell lysates or protein complexes immunoprecipitated (IP) with TLR2 and IB for TLR2 in whole-cell lysates or protein complexes IP with Siglec15 in the indicated groups. e IB for TLR2 in whole-cell lysates or protein complexes IP with Siglec15 in Siglec15^ΔLysM or Siglec15^fl/fl (WT) BMMs to test the effects of sialidase