Figure 4.

The methodology behind synthetic correlated diffusion imaging, which can be summarized as follows. First, multiple native DWI acquisitions are performed using a set of b-values $B=\{b_1,b_2,...,b_N\}$. Second, the native signal acquisitions S are passed into a signal synthesizer to compute synthetic signal acquisitions $\widehat{S}$. Third, the native and synthetic signal acquisitions are mixed together in a calibrated manner to obtain the local correlation of signal attenuation across the acquired signals, which produces a final signal (C) that characterizes the tissue being imaged with greater consistency in dynamic range across machines and protocols.