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a Chemical structure of ASP2453. b Interaction between ASP2453 and KRAS G12C (mean ± SD). c ASP2453, among the proteome in NCI-H1373 cells, selectively binds to KRAS G12C after treatment for 2 h at 30 nmol/L. d Inhibitory activity of ASP2453 on SOS-mediated KRAS G12C-Raf or KRAS WT-Raf interactions (mean ± SEM, three independent experiments).
