Table 2.
Proportion with each primary liver disease by Cancer Alliance.
| ALD | Viral hepatitis | NAFLD | AIH and PBC | Other | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percent | 95% CI | p | Percent | 95% CI | p | Percent | 95% CI | p | Percent | 95% CI | p | Percent | 95% CI | p | |
| England Overall | 21.0% | 17.2% | 16.1% | 3.1% | 42.7% | ||||||||||
| By Cancer Alliance, unadjusted | |||||||||||||||
| West Yorkshire | 21.9% | (19.2–24.8%) | 15.9% | (13.6–18.5%) | 15.2% | (12.9–17.7%) | 2.6% | (1.7–3.9%) | 44.5% | (41.2–47.9%) | |||||
| Humber, Coast & Vale | 19.4% | (15.8–23.7%) | 7.3% | (5.1–10.4%) | 17.3% | (13.8–21.5%) | 2.1% | (1.1–4.1%) | 53.8% | (48.8–58.8%) | |||||
| Cheshire and Merseyside | 27.2% | (24.5–30.1%) | 15.1% | (13.0–17.5%) | 14.8% | (12.7–17.1%) | 4.3% | (3.2–5.8%) | 38.6% | (35.6–41.7%) | |||||
| South Yorkshire, Bassetlaw, North Derbyshire & Hardwick | 17.1% | (14.4–20.1%) | 11.8% | (9.6–14.4%) | 15.7% | (13.2–18.7%) | 3.5% | (2.4–5.2%) | 51.9% | (48.2–55.6%) | |||||
| West Midlands | 20.3% | (18.4–22.3%) | 14.0% | (12.4–15.8%) | 16.2% | (14.5–18.0%) | 3.2% | (2.5–4.2%) | 46.3% | (43.9–48.8%) | |||||
| East Midlands | 18.0% | (15.7–20.6%) | 14.2% | (12.1–16.5%) | 17.0% | (14.8–19.5%) | 4.9% | (3.7–6.4%) | 45.9% | (42.8–49.1%) | |||||
| East of England | 18.4% | (16.6–20.4%) | 17.1% | (15.4–19.1%) | 17.8% | (16.0–19.7%) | 3.6% | (2.8–4.6%) | 43.1% | (40.7–45.5%) | |||||
| South East London | 16.4% | (13.2–20.2%) | 34.0% | (29.7–38.6%) | 11.6% | (8.9–14.9%) | 2.5% | (1.4–4.5%) | 35.4% | (31.0–40.0%) | |||||
| Kent & Medway | 25.1% | (21.1–29.6%) | 13.7% | (10.7–17.4%) | 16.7% | (13.3–20.6%) | 4.2% | (2.6–6.7%) | 40.3% | (35.6–45.2%) | |||||
| Surrey & Sussex | 21.5% | (18.7–24.6%) | 15.7% | (13.3–18.5%) | 16.0% | (13.6–18.8%) | 2.1% | (1.3–3.4%) | 44.7% | (41.2–48.2%) | |||||
| Thames Valley | 22.7% | (19.3–26.6%) | 18.6% | (15.4–22.2%) | 13.8% | (11.1–17.1%) | 1.6% | (0.8–3.1%) | 43.3% | (39.0–47.6%) | |||||
| Peninsula | 23.4% | (19.9–27.2%) | 14.1% | (11.4–17.4%) | 19.5% | (16.3–23.1%) | 3.1% | (1.9–5.0%) | 40.0% | (35.8–44.2%) | |||||
| Somerset, Wiltshire, Avon & Gloucestershire | 20.5% | (17.7–23.5%) | 13.5% | (11.2–16.1%) | 18.3% | (15.7–21.2%) | 2.7% | (1.7–4.1%) | 45.1% | (41.5–48.7%) | |||||
| Wessex | 23.0% | (20.1–26.1%) | 11.9% | (9.8–14.4%) | 19.8% | (17.1–22.8%) | 2.9% | (1.9–4.4%) | 42.4% | (38.9–46.0%) | |||||
| North East & Cumbria | 26.5% | (24.0–29.1%) | 6.9% | (5.5–8.5%) | 20.7% | (18.4–23.1%) | 3.9% | (2.9–5.2%) | 42.1% | (39.2–45.0%) | |||||
| Lancashire & South Cumbria | 22.7% | (19.5–26.3%) | 14.3% | (11.7–17.5%) | 14.0% | (11.4–17.1%) | 2.6% | (1.6–4.3%) | 46.3% | (42.3–50.4%) | |||||
| Greater Manchester | 21.8% | (19.4–24.4%) | 18.4% | (16.2–20.9%) | 13.4% | (11.5–15.6%) | 2.3% | (1.6–3.4%) | 44.0% | (41.0–47.1%) | |||||
| North Central & North East London | 15.2% | (13.0–17.8%) | 41.6% | (38.3–44.9%) | 12.6% | (10.6–15.0%) | 2.4% | (1.5–3.6%) | 28.2% | (25.3–31.3%) | |||||
| North West & South West London | 18.6% | (16.1–21.3%) | <0.001 | 32.6% | (29.6–35.8%) | <0.001 | 11.6% | (9.6–13.9%) | <0.001 | 2.4% | (1.5–3.6%) | 0.008 | 34.9% | (31.8–38.1%) | <0.001 |
| By Cancer Alliance, adjusted for age, sex, deprivation and ethnicity | |||||||||||||||
| West Yorkshire | 20.4% | (17.8–23.3%) | 10.3% | (8.5–12.5%) | 14.2% | (12.1–16.7%) | 1.4% | (0.9–2.2%) | 43.7% | (40.2–47.3%) | |||||
| Humber, Coast & Vale | 17.1% | (13.7–21.1%) | 6.4% | (4.3–9.3%) | 15.9% | (12.7–19.8%) | 1.0% | (0.5–2.1%) | 51.0% | (45.7–56.2%) | |||||
| Cheshire & Merseyside | 23.6% | (21.1–26.4%) | 10.6% | (8.8–12.6%) | 14.1% | (12.1–16.4%) | 2.2% | (1.6–3.1%) | 38.5% | (35.3–41.8%) | |||||
| South Yorkshire, Bassetlaw, North Derbyshire & Hardwick | 14.8% | (12.4–17.6%) | 9.1% | (7.2–11.4%) | 14.5% | (12.1–17.3%) | 1.8% | (1.2–2.7%) | 50.7% | (46.7–54.7%) | |||||
| West Midlands | 19.3% | (17.4–21.3%) | 8.7% | (7.5–10.1%) | 15.5% | (13.8–17.3%) | 1.8% | (1.3–2.4%) | 45.1% | (42.6–47.7%) | |||||
| East Midlands | 15.8% | (13.7–18.1%) | 9.9% | (8.2–11.8%) | 16.4% | (14.2–18.8%) | 2.7% | (2.0–3.7%) | 45.2% | (42.0–48.6%) | |||||
| East of England | 16.0% | (14.3–17.8%) | 13.6% | (12.0–15.5%) | 16.8% | (15.1–18.7%) | 1.8% | (1.3–2.4%) | 41.8% | (39.2–44.3%) | |||||
| South East London | 16.6% | (13.2–20.6%) | 18.4% | (15.0–22.4%) | 13.1% | (10.0–16.9%) | 1.7% | (0.9–3.1%) | 37.7% | (32.8–42.8%) | |||||
| Kent & Medway | 22.3% | (18.6–26.6%) | 11.7% | (8.9–15.3%) | 15.5% | (12.4–19.3%) | 2.1% | (1.2–3.4%) | 38.0% | (33.3–43.1%) | |||||
| Surrey & Sussex | 19.8% | (17.1–22.8%) | 15.4% | (12.7–18.4%) | 14.7% | (12.4–17.4%) | 1.1% | (0.6–1.8%) | 39.7% | (36.1–43.4%) | |||||
| Thames Valley | 20.2% | (17.0–24.0%) | 14.4% | (11.5–17.9%) | 13.2% | (10.5–16.4%) | 0.8% | (0.4–1.6%) | 42.3% | (37.8–46.9%) | |||||
| Peninsula | 20.0% | (16.9–23.6%) | 12.4% | (9.7–15.6%) | 18.1% | (15.1–21.6%) | 1.6% | (1.0–2.7%) | 37.1% | (32.8–41.5%) | |||||
| Somerset, Wiltshire, Avon & Gloucestershire | 18.0% | (15.4–20.8%) | 12.8% | (10.4–15.5%) | 17.1% | (14.5–19.9%) | 1.2% | (0.8–2.0%) | 41.7% | (38.0–45.4%) | |||||
| Wessex | 20.0% | (17.3–22.9%) | 11.1% | (8.9–13.6%) | 18.2% | (15.7–21.1%) | 1.5% | (0.9–2.3%) | 39.0% | (35.4–42.6%) | |||||
| North East & Cumbria | 23.7% | (21.3–26.3%) | 5.8% | (4.6–7.3%) | 19.1% | (16.9–21.4%) | 2.1% | (1.5–2.9%) | 38.3% | (35.4–41.4%) | |||||
| Lancashire & South Cumbria | 19.6% | (16.6–23.0%) | 9.6% | (7.6–12.2%) | 13.2% | (10.7–16.2%) | 1.4% | (0.8–2.4%) | 45.9% | (41.6–50.3%) | |||||
| Greater Manchester | 19.3% | (17.1–21.8%) | 11.5% | (9.8–13.5%) | 13.0% | (11.1–15.2%) | 1.3% | (0.9–2.0%) | 44.8% | (41.6–48.1%) | |||||
| North Central & North East London | 15.5% | (13.1–18.2%) | 22.0% | (19.2–25.0%) | 14.3% | (11.9–17.0%) | 1.9% | (1.2–3.0%) | 31.9% | (28.5–35.5%) | |||||
| North West & South West London | 19.6% | (17.0–22.6%) | <0.001 | 19.4% | (16.9–22.1%) | <0.001 | 12.4% | (10.3–14.8%) | 0.001 | 1.5% | (1.0–2.4%) | 0.023 | 36.4% | (33.0–39.9%) | <0.001 |
| Covariate odds ratios (95%CI) | |||||||||||||||
| Per year increase in age | 0.97 | (0.96–0.97) | <0.001 | 0.92 | (0.91–0.92) | <0.001 | 1.02 | (1.02–1.03) | <0.001 | 1.01 | (1.00–1.02) | 0.005 | 1.06 | (1.06–1.06) | <0.001 |
| Female | 0.43 | (0.38–0.48) | <0.001 | 0.77 | (0.68–0.87) | <0.001 | 1.11 | (1.01–1.23) | 0.039 | 9.73 | (7.95–11.92) | <0.001 | 1.11 | (1.02–1.20) | 0.013 |
| Per quintile increase in deprivation | 1.00 | (0.97–1.03) | 0.829 | 1.20 | (1.15–1.24) | <0.001 | 0.97 | (0.94–1.00) | 0.091 | 0.88 | (0.83–0.95) | <0.001 | 0.95 | (0.93–0.98) | <0.001 |
| Ethnicity | |||||||||||||||
| White | ref | ref | ref | ref | ref | ||||||||||
| Black | 0.14 | (0.09–0.21) | <0.001 | 3.69 | (2.87–4.74) | <0.001 | 0.28 | (0.17–0.47) | <0.001 | 0.08 | (0.01–0.57) | 0.012 | 1.17 | (0.92–1.49) | 0.213 |
| South Asian | 0.28 | (0.21–0.37) | <0.001 | 3.76 | (3.12–4.52) | <0.001 | 1.11 | (0.90–1.38) | 0.338 | 0.43 | (0.22–0.82) | 0.011 | 0.75 | (0.63–0.90) | 0.002 |
| Other Asian | 0.19 | (0.12–0.29) | <0.001 | 3.75 | (2.92–4.81) | <0.001 | 0.85 | (0.61–1.18) | 0.324 | 0.64 | (0.29–1.39) | 0.257 | 0.85 | (0.66–1.09) | 0.193 |
| Other Ethnicity | 0.40 | (0.28–0.57) | <0.001 | 3.53 | (2.69–4.62) | <0.001 | 0.77 | (0.53–1.12) | 0.179 | 0.53 | (0.21–1.31) | 0.169 | 0.68 | (0.51–0.90) | 0.007 |
| Not Known | 0.63 | (0.51–0.77) | <0.001 | 0.85 | (0.67–1.09) | 0.196 | 0.47 | (0.36–0.61) | <0.001 | 0.40 | (0.22–0.73) | 0.003 | 2.23 | (1.89–2.62) | <0.001 |