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. 2022 Feb 16;9:772380. doi: 10.3389/fcell.2021.772380

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Copyright © 2022 Liu, Liu, Bian, Zhang, Wang, Chen, Jiang, Li, Chen, Xue, Li, Liu, Liu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Compared with normal tissues, ferroptosis-related gene SLC7A11 was upregulated in breast cancer tissues and contributed to poor survival. (A) The differentially expressed genes (DEGs) were identified between TP and NT with in breast cancer patients. Volcano plot shows the gene statistical significance with |log2FC| > 1.5 and FDR <10^-10. The green points were ferroptosis-related genes. (B,C) Comparison of SLC7A11 expression in different subgroups. Normal and tumor (B); ER-positive and ER-negative (C). (D–F) Kaplan–Meier curves of overall survival (OS) in breast cancer according to SLC7A11 expression. Overall survival analysis (D); Subgroup analyses of OS in ER-positive (E) and ER-negative (F).