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. 2022 Feb 16;9:772380. doi: 10.3389/fcell.2021.772380

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Copyright © 2022 Liu, Liu, Bian, Zhang, Wang, Chen, Jiang, Li, Chen, Xue, Li, Liu, Liu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between ESR1 and SLC7A11 in ER-positive cancers. (A) Scatter plots for correlation analysis of ESR1 and SLC7A11. The dark gray line means a linear regression line and the gray region is 95% confidence region. (B) Kaplan–Meier curve of OS in ER-positive cancers according to ESR1 expression. (C) IP assay of MCF-7 cells transfected with a plasmid expressing FLAG-tagged SLC7A11. (D–G) Western blot and qRT-PCR analysis showed that si-ESR1 reduced SLC7A11 expression in MCF-7 (D,F,G) and ZR-75-1 (E). (H) Effect of ESR1 on SLC7A11 transcription by double fluorescein-reporter enzyme activity in MCF-7. Shown is mean ± SD, n ≥ 3, *p < 0.05; **p < 0.01.