Table 3.
Cox regression model.
| HR | 95% CI | df | p | ||
|---|---|---|---|---|---|
| Lower | Upper | ||||
| Reference: no resection but good resectable | 3 | <0.001 | |||
| Complete resection | 0.667 | 0.494 | 0.902 | 1 | 0.009 |
| Incomplete resection | 0.731 | 0.513 | 1.041 | 1 | 0.082 |
| No resection, bad resectable | 1.839 | 1.310 | 2.581 | 1 | <0.001 |
| MGMT-unmethylated | Reference | ||||
| MGMT-methylated | 0.593 | 0.765 | 0.460 | 1 | <0.001 |
| Age at diagnosis (decrease per decade) | 0.853 | 0.766 | 0.949 | 1 | 0.003 |
| KPS at progression <70 | Reference | ||||
| KPS at progression ≥70 | 0.234 | 0.135 | 0.404 | 1 | <0.001 |
| Reference: no therapy | 3 | <0.001 | |||
| Radiotherapy | 0.264 | 0.121 | 0.575 | 1 | 0.001 |
| Chemotherapy | 0.192 | 0.109 | 0.337 | 1 | <0.001 |
| Radiochemotherapy | 0.109 | 0.014 | 0.832 | 1 | 0.03 |
| KPS70 at progression * | 3 | 0.003 | |||
| Therapy arm | |||||
| KPS70 at progression * | 3.954 | 1.622 | 9.637 | 1 | 0.002 |
| Radiotherapy | |||||
| KPS70 at progression * | 3.035 | 1.577 | 5.841 | 1 | 0.001 |
| Chemotherapy | |||||
| KPS70 at progression * | 5.500 | 0.671 | 45.056 | 1 | 0.112 |
| Radiochemotherapy | |||||
MGMT, O6-methylguanine-DNA-methyltransferase; KPS, Karnofsky Performance Status. KPS70 at progression * therapy arm show the interactions between the patient’s condition and the therapies used.