Table 2.
Multivariate analysis of factors independently associated with liver fibrosis.
| Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Non-fibrotic (n = 224) | Fibrotic (n = 159) | p-value | OR [95%CI] | p-value | |
| Sex distribution (Males, %) | 43.8% | 39.6% | 0.413 | ||
| BMI > 30 kg/m2 | 31.7% | 48.5% | 0.001 | 2.11[1.31–3.41] | 0.002 |
| Age (years) | 44.8 ± 12.9 | 48.7 ± 13.1 | 0.005 | 1.02[1.01–1.05] | 0.003 |
| T2DM (yes) | 9% | 28.3% | ≤ 0.001 | 2.66[1.39–5.09] | 0.003 |
| AST (IU/mL) | 29.7 ± 21.7 | 39.3 ± 24.1 | ≤ 0.001 | ||
| ALT (IU/mL) | 41 + 33.1 | 63.1 ± 44 | ≤ 0.001 | 1.01[1.01–1.03] | ≤ 0.001 |
| GGT (IU/mL) | 70.5 ± 79.4 | 90.5 ± 85.3 | 0.023 | ||
| Triglycerides (mg/dL) | 123.4 ± 63 | 157.2 ± 92.5 | 0.008 | ||
| Total cholesterol (mg/dL) | 190.8 ± 45.6 | 191.4 ± 43.1 | 0.941 | ||
| Albumin (mg/dL) | 4279 ± 329.4 | 4424.1 ± 463.5 | 0.076 | ||
| CPS1 A-allele (AA/AC vs CC) | 50.4% (113/224) | 39.6% (63/159) | 0.036 | 0.62 [0.39–0.99] | 0.047 |
BMI body mass index, T2DM type 2 diabetes mellitus, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma glutamil transferase, CPS1 carbamoyl phosphate synthetase-1. Significant values are in Italics.