Table 4.
Examples of Preclinical Cancer Studies in Swine
| Model | Application | Cancer of interest | Reference |
|---|---|---|---|
| A. Immunocompromised pigs | |||
| RAG2−/− IL2Rg−/Y | Proof of concept study for irreversible electroporation ablation | Pancreatic | (Hendricks-Wenger et al. 2021) |
| RAG2 −/− | Diagnostic methods and minimally invasive surgeries | Multiple, metastasis | (Kurihara et al. 2019) |
| B. Genetic porcine models | |||
| Cre inducible KRASG12D TP53R167H | Intra-arterial catheterization and angiography | Pancreatic | (Boas et al. 2020) |
| Melanoma swine model | Photoacoustic, ultrasound, optical coherence tomography | Melanoma | (Kratkiewicz et al. 2019) |
| Cre inducible KRASG12D TP53R167H | Hyperthermia with bexarotone and ultrasound ablation | Hepatocellular carcinoma | (Misra et al. 2015) |
| Cre inducible KRASG12D TP53R167H | Transarterial embolization | Liver cancer | (Nurili et al. 2021) |
| C. Normal immunocompetent pigs | |||
| Göttingen mini pig | FLASH radiotherapy | Multiple, general | (Vozenin et al. 2019) |
| Yorkshire | Image guided radiation therapy | Pancreatic | (Rao et al. 2018) |
| Potbellied Vietnamese minipig | Microwave ablation therapy | Breast | (Ortega-Palacios et al. 2018) |
| NS | Electrochemotherapy | Pancreatic | (Dežman et al. 2020) |
| NS | High intensity focused ultrasound | Pancreatic | (Huang et al. 2019) |
| NS | Surgery | Gastric and colon | (Choi et al. 2018) |
| NS | Thermal accelerant gel for microwave ablation | Lung | (Maxwell et al. 2019) |
| Göttingen x Yucutan | Glutamine antagonist drug testing | Glioblastoma | (Rais et al. 2016; Nedelcovych et al. 2017) |
Note.— For immunocompromised and genetic porcine models, the genetic background is provided, whereas for normal immunocompetent pigs, the pig strain is provided. NS = not specified