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. 2022 Feb 16;13:822111. doi: 10.3389/fphar.2022.822111

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Copyright © 2022 Chackal, Eng, Rodrigues, Matthews, Pagé-Lariviére, Avery-Gomm, Xu, Tufenkji, Hemmer and Mennigen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Radar chart diagrams summarizing organismal level effects of different exposure treatments on the metabolic phenotype in developing zebrafish: Control, 2.5 ppm PS and 25 ppm PS exposures (A) Control and 10 ppt BDE-47 exposure, (B) Control and combined exposures of 2.5 ppm + 10 ppt BDE-47 and 25 ppm + 10 ppt BDE-47, (C) in comparison to vehicle control. Note that all average treatment group values have been normalized to control values (=1) and in some cases inverted so that datapoints >1 indicate quantified parameters with a positive contribution to energy balance, while datapoints <1 indicate parameters negatively contributing to organismal energy balance. Endpoints with significant effects of treatment are highlighted by surrounding rectangular shapes.