TABLE 2.

Model organisms used to study the roles of CLN genes and proteins in autophagy. Alignments were generated using NCBI, Protein BLAST (default search parameters) and the Uniprot ID, of each homolog as query sequences.

Human protein	Size (aa)	Model organism	Homolog	Uniprot ID	Size (aa)	% identity b	% similarity c
PPT1	306	D. melanogaster	Ppt1	Q9W3C7	314	55	72
		M. musculus	PPT1	O88531	306	86	92
TPP1	563	D. discoideum	Tpp1A	Q55CT0	600	37	52
		M. musculus	TPP1	O89023	562	88	94
CLN3	438	S. pombe	Btn1p	Q9US09	396	32	47
		D. discoideum	Cln3	Q54F25	421	27	45
		M. musculus	CLN3	Q61124	438	86	90
DNAJC5	198	C. elegans	DNJ-14	E5QCE7	217	51	68
		M. musculus	DNAJC5	P60904	198	99	99
CLN5	358	D. discoideum	Cln5	Q553W9	322	30	47
		M. musculus	CLN5	Q3UMW8	341	78	86
		O. aries	CLN5	A2TJ54	361	86	91
CLN6	311	M. musculus	CLN6	Q3U466	308	90	93
		O. aries	CLN6	Q1PAG8	310	91	93
MFSD8	518	D. melanogaster	Cln7	Q9VS51	546	35	57
		M. musculus	MFSD8	Q8BH31	519	82	91
CLN8	286	M. musculus	CLN8	Q9QUK3	288	85	90
CTSD	412	D. discoideum	CtsD	O76856	383	48	65
		H. armigera	CtsD	AYP72766 a	384	54	68
		M. musculus	CTSD	P18242	410	83	91
GRN	593	M. musculus	GRN	P28798	589	75	84
ATP13A2	1,180	C. elegans	CATP-6	F5GUA7	1,207	40	57
		D. melanogaster	DmeI/Anne	L0MLL1	1,290	37	54
		D. rerio	Atp13a2	A1A5E5	1,170	52	67
		O. latipes	Atp13a2	H2L3J0	1,143	50	65
		M. musculus	ATP13A2	Q9CTG6	1,169	85	90

^aNCBI/GenBank identifier.

^bExact amino acid match.

^cSimilar amino acid match (e.g., both polar).