TABLE 1.
PKA subunits and major PKA regulatory proteins. Known PKA players in budding yeast S. cerevisiae and mammalian systems. See text for references. + Cyr1 can localize to multiple membranes including in the mitochondria, ER, and plasma membrane (Belotti et al., 2012). * Yeast cells lack proteins orthologs to AKAPs but have other proteins that may serve similar roles, see text for details.
| Regulator | Yeast | Mammals |
|---|---|---|
| PKA C subunits | Tpk1, Tpk2, Tpk3 | Cα (splice variants Cα1, Cα2 and Cα3) |
| Cβ (splice variants Cβ1, Cβ2, Cβ3, Cβ4, Cβ3ab Cβ3b, Cβ3abc, Cβ4ab, Cβ4b, and Cβ4abc) | ||
| Cγ | ||
| PKA R subunits | Bcy1 | RIα |
| RIIα | ||
| RIβ | ||
| RIIβ | ||
| ACs | Cyr1+ | AC1-9 (plasma membrane anchored) |
| AC10 (soluble AC) | ||
| cAMP PDE Isoforms | Pde1, Pde2 | PDE4, PDE7, PDE8 (cAMP specific) |
| PDE1, PDE2, PDE3, PDE10, PDE11 (cAMP and cGMP specific) | ||
| AKAPs | None* | >50 members (additional splice variants) |