Table 3.
Constipation.
| First author | Type of study | Sample size (n) | Intervention | Outcomes |
|---|---|---|---|---|
| Huang et al. (70) | Systematic review and meta-analysis |
498 <18 years |
Different probiotic strains tested in different studies (L. rhamnosus, L. casei, S. thermophilus, B. breve, L. acidophilus, B. infantis, L. sporogenes) | Probiotics significantly increased the stool frequency |
| Wojtyniak et al. (72) | Systematic review |
515 6 months to 16 years |
L. rhamnosus casei Lcr35 vs. placebo Other probiotics studied in single trials (L. rhamnosus GG, L. reuteri DSM 17938, B. lactis DN-173 010, S. thermophilus CNCM I-1630, B. longum, Protexin*) |
No difference regarding frequency of fecal incontinence or abdominal pain. No evidence to recommend probiotics in constipation. |
| San Gomes et al. (73) | Systematic review |
564 < 19 years |
Different probiotic strains evaluated (L. rhamnosus GG, L. casei rhamnosus Lcr35, L. reuteri, B. lactis, B. longum, Protexin*, Probiotic mix**) | No evidence to recommend probiotics in the treatment of constipation in pediatrics |
*
Protexin: L. casei PXN 37, L. rhamnosus PXN 54, S. thermophiles PXN 66, Brief bifidobacterium PXN 25, L. acidophilus PXN 35, B. infantis PXN 27 and L. bulgaricus PXN 39.
**
Probiotic mix: Brief bifidobacterium M-16 V, Infant Bifidobacterium M-63 and Bifidobacterium longum BB536.