TABLE 1.

SLC genes are strongly downregulated in Pals1 haploinsufficient kidneys. More than 100 genes of the SLC superfamily (Pizzagalli et al., 2021) are downregulated in Pals1-haploinsufficient kidneys (see Supplementary Material 9; Weide et al., 2017). The table shows ten SLC genes i) that are known to be highly expressed in the kidney, ii) functionally and phylogenetically conserved in mammalian species (mouse, dog, human) and iii) among the most regulated genes identified in the transcriptome of Pals1-deficient kidneys.

Gene	Alias	Function	Nephron localization	Fold change	References
Slc5a2	SGLT2	Sodium glucose cotransporter	Proximal tubules at the apical brush border (BBM) membrane	−5.6	Vallon et al. (2011), Wright et al. (2011), Sabolić et al. (2012), and Vrhovac et al. (2015)
Slc10a2	ASBT, IABT, ISBT, NTCP2	Sodium bile salt cotransport	Proximal tubules at the apical brush border (BBM) membrane	−5.3	Hagenbuch and Dawson (2004)
Slc16a4	MCT4,MCT5, MOT5	Monocarboxylate transporter	Unknown (basolateral in MDCK cells)	−9.1	Deora et al. (2005) and Halestrap (2013)
Slc16a14	MCT14, MOT14		Human: Unknown Mouse: TALH	−5.4	Halestrap (2013) and Knopfel et al. (2017)
Slc22a2	OCT2	Organic cation/anion/zwitterion transporter family	Proximal tubules at the basolateral membrane (BLM)	−2.9	Holle et al. (2011), Koepsell (2013), and Schulze et al. (2017)
Slc22a7	OAT2, NLT		Proximal tubules at BLM	−13.8	Nigam et al. (2015) and Breljak et al. (2016)
Slc22a8	OAT3		Proximal tubules at the BLM	−4.4	Nigam et al. (2015) and Breljak et al. (2016)
SLC22a13	OCTL1, OCTL3, OAT10, ORCTL3		BLM of type A intercalated cells (rat)	−3.7	Schulz et al. (2014)
SLC34a3	NPT2c	Type II sodium-phosphate cotransporter	Proximal tubules at the apical BBM membrane	−11.2	Dasgupta et al. (2014) and Levi et al. (2019)
SLC39a5	ZIP5, LZT-Hs7	Metal (Zinc) ion transporter	unknown	−3.9	Wang et al. (2004) and Jeong and Eide (2013))