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. 2021 Dec 7;28(2):153–171. doi: 10.1093/humupd/dmab039

Figure 2.

Figure 2.

Endometrial epithelial stem cell niche. (A) Chromogenic immunostaining of cytochrome C oxidase (CCO) in the human endometrium highlighting the extent of CCO-deficient clonal expansion (blue glands). ×20 magnification (scale bar = 500 μm). (B) 2D rendering of the hypothetical origin of partially CCO-deficient functionalis glands arising from basalis-resident stem cells. Adapted from Tempest et al. (2020). (C) Putative stem cell niches in the endometrial lumen (leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5++), stage-specific embryonic-antigen 1 (SSEA-1+), SRY-box 9 (SOX9+) and basalis (LGR5+, SSEA-1++, SOX9++, N-cadherin+, nuclear β-catenin+).