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. 2022 Feb 16;12:808982. doi: 10.3389/fmicb.2021.808982

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Copyright © 2022 Wang, Su, Liu, Li, Sun, Liu, Xue, Chang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antiviral effect and cell viability of AZT at different concentrations. (A) Cell viability of DF-1 cells after AZT treatment at 0.1, 0.5, 1, 2, 5, and 10 μg/ml for 48 h by CCK-8 assay. The experiment was repeated three times. The error bars represent the SD. ^**P < 0.01 and ns represents not statistically significant. (B) Dose-response curve of AZT reveals the dose relationship between AZT and ALV-J. The x-axis represents the log of the concentration of AZT (μg/ml), and the y-axis represents the inhibition rate of virus (%), which was calculated according to Equation 2 and represents the proportion of virus titer reduction under drugs. The red dotted line indicates the position of 50% inhibition rate. The experiment was repeated eight times. The error bars represent the SD.