TABLE 3.

Comparisons of GM, WM, and CSF tissue fractions between NPSLE and non-NPSLE across test sets in all six trials and in the entire study population.

	NPSLE	Non-NPSLE	p-value
Test sets
Trial 1	n = 9	n = 9
GM	0.43 ± 0.02	0.42 ± 0.03	0.139
WM	0.35 ± 0.01	0.35 ± 0.03	0.804
CSF	0.22 ± 0.03	0.24 ± 0.05	0.256
Trial 2	n = 9	n = 9
GM	0.40 ± 0.03	0.39 ± 0.03	0.441
WM	0.34 ± 0.02	0.34 ± 0.03	0.777
CSF	0.26 ± 0.03	0.27 ± 0.04	0.592
Trial 3	n = 9	n = 9
GM	0.40 ± 0.02	0.39 ± 0.02	0.417
WM	0.34 ± 0.02	0.34 ± 0.02	0.914
CSF	0.26 ± 0.04	0.27 ± 0.03	0.508
Trial 4	n = 9	n = 9
GM	0.38 ± 0.04	0.40 ± 0.03	0.366
WM	0.33 ± 0.02	0.35 ± 0.02	0.116
CSF	0.29 ± 0.05	0.26 ± 0.03	0.140
Trial 5	n = 9	n = 9
GM	0.37 ± 0.03	0.41 ± 0.02	0.023*
WM	0.33 ± 0.01	0.34 ± 0.02	0.050
CSF	0.30 ± 0.04	0.25 ± 0.04	0.019*
Trial 6	n = 9	n = 9
GM	0.41 ± 0.03	0.40 ± 0.02	0.537
WM	0.33 ± 0.01	0.37 ± 0.03	0.006*
CSF	0.26 ± 0.04	0.24 ± 0.04	0.244
Total populations	n = 43	n = 120
GM	0.40 ± 0.03	0.40 ± 0.03	0.478
WM	0.34 ± 0.02	0.34 ± 0.03	0.126
CSF	0.26 ± 0.04	0.25 ± 0.05	0.252

Tissue volumes were normalized to total intracranial volume resulting in (unitless) tissue fractions. These are expressed as mean ± SD. Differences between NPSLE and non-NPSLE were calculated with unpaired t-tests and expressed as p values, *p < 0.05. values in bold represent statistically significant differences between the two cohorts.