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. 2022 Feb 16;13:781273. doi: 10.3389/fimmu.2022.781273

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Copyright © 2022 Wu, You, Cui, Yang, Lin, Chen, Xu, Lian and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of the underlying mechanism in renal IRI-induced AKI. Inhibiting NET formation by neutrophils depletion using anti-Ly6G (1A8) or C3 KO significantly ameliorated the resultant renal injury. In ischemic AKI, there is increased cleavage of C3 to C3a, which probably binds to C3aR on the surface of neutrophils and then activates PAD4, leading to the release of NETs.