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. 2022 Feb 16;13:781273. doi: 10.3389/fimmu.2022.781273

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Copyright © 2022 Wu, You, Cui, Yang, Lin, Chen, Xu, Lian and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutrophil depletion preserves renal function in IRI mice. (A) Serum creatinine, and (B) urea nitrogen of WT mice injected with 1A8 or IgG, n = 5–6/group. (C) Histology of IRI kidney in the indicated treatments. HE staining (Row 1). ICAM-1 immunohistochemistry (Row 2). MPO immunohistochemistry (Row 3). Ly6G immunohistochemistry (Row 4). Scale bar = 200 μM. n = 5–6/group. The percentage of positive neutrophil staining in 10 non-overlapping fields was quantified using Image J software. (D) Score for histopathology of tubular damage after renal IRI using HE-stained renal tissue sections. (E) ICAM-1-positive area. (F) MPO-positive area. (G) Ly6G-positive area. *P < 0.05, **P < 0.01. Data are presented as mean ± SD.