Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 16;13:843872. doi: 10.3389/fphar.2022.843872

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Li, Liu, Li, Dong, Wang, Tan, Wang, Jiang, Lei, Li, Sun, Jiang and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram of the therapeutic mechanism of combined use of bicyclol and berberine against NAFLD. Bicyclol enhanced lipolysis through p62-Nrf2-CES2 signaling axis and improved β-oxidation through p62-Nrf2-PPARα signaling axis, while berberine suppressed the de novo lipogenesis by inhibiting protein expressions of ACC and FAS, along with the regulation of lipid metabolisms via the gut microbiota, and thus co-facilitating to ameliorate the occurrence and progress of NAFLD. The green arrow shows a stimulatory effect, the red flathead shows an inhibitory effect.