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. 2022 Feb 16;13:845185. doi: 10.3389/fphar.2022.845185

FIGURE 2.

FIGURE 2

Pharmacological targets of the NLRP3 inflammasome (LPS: lipopolysaccharide; TLR: Toll-like receptor; NF-κB: nuclear factor kappa B; mtROS: mitochondrial ROS; mtDNA: mitochondrial DNA; NLRP3: nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3; ASC: apoptosis-associated speck-like protein containing a CARD; PG: progesterone; TSG: 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside; Qu: Quercetin; MNS: 3,4-methylenedioxy-β-nitrostyrene; CARD: caspase recruitment domain; NACHT: nucleotide-binding and oligomerization domain; PYD: pyrin domain; LRR: leucine-rich repeat).