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. 2022 Feb 16;13:780945. doi: 10.3389/fimmu.2022.780945

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Copyright © 2022 Chicana, Abbasizadeh, Burns, Taglinao, Spencer and Manilay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disruption in blood-bone marrow barrier revealed by intravital microscopy. Blood vessel microenvironment comparisons of control and VhlcKO mice at 6-week (n=4), 10-week (n=4) and 6-month (n=5) timepoints. (A) Representative contrast adjusted max intensity projections of the calvarial BM in control and VhlcKO mice by age; White: blood vessel (Rhodamine B Dextran, 70 kDa); scale bar: 50 μm; quantification of calvarial BM (B) blood vessel leakage, (C) vascular permeability, and (D) blood flow velocity. *p<0.05, **p<0.01, ****p<0.0001, Mann-Whitney test.