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. 2022 Feb 16;13:811430. doi: 10.3389/fimmu.2022.811430

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Copyright © 2022 Rocha, Fagre, Latham, Cummings, Aboellail, Reigan, Aldaz, McDermott, Popichak, Kading, Schountz, Theise, Slayden and Tjalkens

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduction of immune cell infiltration and broncho-interstitial pneumonia by PT150 treatment. Overall hypercellularity within lung tissue, resulting in pathological broncho-interstitial pneumonia, was determined using ROI delineations on hematoxylin and eosin-stained sections for all groups: days 3, 5 and 7 post-infection. (A–C) SARS-CoV-2 + vehicle; (D–F), SARS-CoV-2 + 30 mg/Kg/day PT150; (G–I), SARS-CoV-2 + 100 mg/Kg/day PT150; B, Control + vehicle. (J), Quantification of the total area of the lung tissue affected with broncho-interstitial pneumonia was conducted using automated focal point determination within ROIs following manual thresholding (K). Pseudo colored grayscale images of H&E sections are depicted in blue, overlaid with ROI’s detected by intensity thresholding in red. *p<0.01, ***p<0.001, ****p<0.0001; N=6 hamsters/group.