TABLE 2.

Discriminative pathways for RW and CC groups as identified by LEfSe analysis.

Pathway	Group discriminated	q-value	LDA score
PWY-7219: adenosine ribonucleotides de novo biosynthesis	RW	0.006	4.25
PWY-7229: superpathway of adenosine nucleotides de novo biosynthesis I	CC	0.012	4.03
PWY-6126: superpathway of adenosine nucleotides de novo biosynthesis II	CC	0.020	3.98
PWY-6125: superpathway of guanosine nucleotides de novo biosynthesis II	CC	0.014	3.75
PWY-7383: anaerobic energy metabolism (invertebrates, cytosol)	CC	0.001	3.63

LEfSe analysis was performed by Kruskal–Wallis test and pairwise Wilcoxon test.